T- AND B-CELL INTERACTIONS IN AUTOIMMUNE SYNDROMES

We have reviewed briefly some of the individual capabilities of T and B cells and how these can be modified by interactions between the two cell lines. Evidence that T cells have their own distinct receptors for antigens, yet under certain circumstances may bind IgM or IgG produced by B cells, has b...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1975-06, Vol.256 (1), p.105-116
Main Authors: Cooper, M. D., Keightley, R. G., Webb, S. R.
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Antigen-Antibody Complex
Antigen-Antibody Reactions
Arthritis, Rheumatoid - immunology
Autoantibodies
Autoimmune Diseases - immunology
B-Lymphocytes - immunology
Binding Sites, Antibody
Chickens
Humans
Immunoglobulin G
Immunoglobulin M
Mice
Rheumatoid Factor
T-Lymphocytes - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have reviewed briefly some of the individual capabilities of T and B cells and how these can be modified by interactions between the two cell lines. Evidence that T cells have their own distinct receptors for antigens, yet under certain circumstances may bind IgM or IgG produced by B cells, has been particularly emphasized. The probability that B cells, in turn, may bind the antigen receptor of T-cell origin reflects the balanced nature of an intricate communication system in which interactions between antigens, antigen receptors, and binding sites for these receptors all serve to modulate the integrated functioning of T and B cells. It is suggested that this communication system is disturbed in patients with rheumatoid arthritis; specifically, it is proposed that defective feedback activity of IgG-antigen complexes on activated T cells may exist in some patients and could result in unchecked and harmful T-cell activity in the joint. Therapeutic implications of this idea are mentioned.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1975.tb36040.x