Activity of phasic neurosecretory cells during haemorrhage

APPROXIMATELY 25% of the neurones projecting to the neurohypophysis from the paraventricular (PV) and supraoptic (SO) nuclei of the hypothalamus fire phasically and such a pattern is seldom seen in other hypothalamic cells 1 . Phasic neurones respond to osmotic stimuli 2 but are rarely activated by...

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Bibliographic Details
Published in:Nature (London) 1975-11, Vol.258 (5530), p.82-84
Main Authors: WAKERLEY, J. B., POULAIN, D. A., DYBALL, R. E. J., CROSS, B. A.
Format: Article
Language:English
Subjects:
Action Potentials
Animals
Blood Pressure
Female
Hemorrhage - physiopathology
Humanities and Social Sciences
Hypothalamus - physiopathology
Lactation
letter
multidisciplinary
Paraventricular Hypothalamic Nucleus - metabolism
Paraventricular Hypothalamic Nucleus - physiopathology
Pregnancy
Rats
Science
Science (multidisciplinary)
Time Factors
Vasopressins - blood
Vasopressins - metabolism
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Summary:APPROXIMATELY 25% of the neurones projecting to the neurohypophysis from the paraventricular (PV) and supraoptic (SO) nuclei of the hypothalamus fire phasically and such a pattern is seldom seen in other hypothalamic cells 1 . Phasic neurones respond to osmotic stimuli 2 but are rarely activated by suckling 1,3 . It is tempting therefore, to associate these cells with the secretion of vasopressin rather than oxytocin. The functional relationship of their phasic pattern to hormone release, however, remains obscure. We have studied phasic PV neurones during haemorrhage, which releases vasopressin, sometimes with small amounts of oxytocin 4 . Haemorrhage evoked changes in phasic units over a period long enough for a detailed analysis of their behaviour. Our results show the importance of pattern modulation in phasic neurones and suggest that the mechanism for vasopressin release differs from that described for oxytocin release during suckling 1,3 .
ISSN:0028-0836
1476-4687
DOI:10.1038/258082a0