Human serum lyses RNA tumour viruses

ALTHOUGH there is agreement that oncornaviruses infect and are associated with malignancies in mice, cats and chickens 1 , the evidence for oncornavirus infection in man remains controversial 2 . Similarly, antibodies to oncornavirus antigens have been detected in laboratory animals 3–7 , but there...

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Published in:Nature (London) 1975-10, Vol.257 (5527), p.612-614
Main Authors: WELSH, RAYMOND M, COOPER, NEIL R, JENSEN, FRED C, OLDSTONE, MICHAEL B. A
Format: Article
Language:English
Subjects:
AKR murine leukemia virus - immunology
Antiviral Agents
Avian Myeloblastosis Virus - immunology
Blood
Complement C2
Complement C4
Complement System Proteins
Friend murine leukemia virus - immunology
Humanities and Social Sciences
Humans
letter
Leukemia Virus, Feline - immunology
Moloney murine leukemia virus - immunology
multidisciplinary
Oncogenic Viruses - immunology
Rauscher Virus - immunology
RNA Viruses - immunology
Science
Science (multidisciplinary)
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Summary:ALTHOUGH there is agreement that oncornaviruses infect and are associated with malignancies in mice, cats and chickens 1 , the evidence for oncornavirus infection in man remains controversial 2 . Similarly, antibodies to oncornavirus antigens have been detected in laboratory animals 3–7 , but there are few data indicating the presence of such antibodies in humans 3,8,9 . These findings suggest that man possesses a natural defence mechanism which inhibits or interferes with oncornavirus infection and replication. We report here evidence for such a mechanism.
ISSN:0028-0836
1476-4687
DOI:10.1038/257612a0