An engineering model of dynamic cardiomyoplasty. II. Clinical applications

Previously, a modification to the Sunagawa engineering model for the isolated left ventricle and arterial system was proposed and validated for dynamic cardiomyoplasty in an acute goat preparation. To test the hypothesis that this model may be applied to the clinical scenario in cardiomyoplasty pati...

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Bibliographic Details
Published in:Annals of biomedical engineering 1998-05, Vol.26 (3), p.454-461
Main Authors: CHEN, F. Y, AKLOG, L, DEGUZMAN, B. J, LAUTZ, D. B, AHMAD, R. M, LAURENCE, R. G, COUPER, G. S, COHN, L. H, MCMAHON, T. A
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Biomechanical Phenomena
Cardiomyoplasty - methods
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Heart - physiopathology
Heart Failure - physiopathology
Heart Failure - surgery
Humans
Intensive care medicine
Medical sciences
Models, Cardiovascular
Stroke Volume
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Summary:Previously, a modification to the Sunagawa engineering model for the isolated left ventricle and arterial system was proposed and validated for dynamic cardiomyoplasty in an acute goat preparation. To test the hypothesis that this model may be applied to the clinical scenario in cardiomyoplasty patients, we predicted human stroke volume using the model with human clinical data from the literature. Predicted stroke volume correlated well with published stroke volume in patients who have had the dynamic cardiomyoplasty procedure. These results suggest that the modest hemodynamic improvement commonly reported after the procedure is performed may be due to diminished latissimus dorsi strength after transformation. The validity of both the original Sunagawa model and the previously proposed modification for dynamic cardiomyoplasty is further supported with these results. A nomogram methodology for predicting stroke volume after dynamic cardiomyoplasty for any particular patient is presented.
ISSN:0090-6964
1573-9686
DOI:10.1114/1.37