Myocardial performance and N2O analgesia in coronary-artery disease

Inhalation of 40 per cent N2O by nine patients who had occlusive disease in two or more coronary arteries with elevation of left ventricular end-diastolic pressures (LVEDP) significantly decreased arterial pressure (average 5 per cent) and myocardial contractility as measured by dP/dt/CPIP (average...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1976-01, Vol.44 (1), p.16-20
Main Authors: Eisele, J H, Reitan, J A, Massumi, R A, Zelis, R F, Miller, R R
Format: Article
Language:English
Subjects:
Adult
Anesthesia, Inhalation
Cardiac Catheterization
Coronary Disease - physiopathology
Female
Heart - drug effects
Heart - physiopathology
Hemodynamics - drug effects
Humans
Male
Middle Aged
Myocardial Contraction - drug effects
Nitrous Oxide - pharmacology
Pressure
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Summary:Inhalation of 40 per cent N2O by nine patients who had occlusive disease in two or more coronary arteries with elevation of left ventricular end-diastolic pressures (LVEDP) significantly decreased arterial pressure (average 5 per cent) and myocardial contractility as measured by dP/dt/CPIP (average 14 per cent), and increased LVEDP (average 21 per cent). N2O had no significant effect in four patients who had angina without angiographically demonstrable coronary arterial disease. It is concluded that N2O depresses myocardial function in patients who have occlusion of the coronary arteries and impaired left ventricular function.
ISSN:0003-3022
DOI:10.1097/00000542-197601000-00003