ADRENERGIC RECEPTIVE MECHANISM IN THE PULMONARY CIRCULATION IN DOGS

The pulmonary circulatory changes caused by adrenergic drugs using several techniques have been demonstrated by many investigators. The pulmonary arterial pressure and the pulmonary resistance increase with epinephrine, levarterenol and phenylephrine (1-4). Isoproterenol reduces the pulmonary arteri...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of pharmacology 1963/04/01, Vol.13(1), pp.18-26
Main Authors: TAKASAKI, KOICHIRO, AHLQUIST, RAYMOND P.
Format: Article
Language:English
Subjects:
Adrenergic Agents
Animals
Blood Pressure
Blood Pressure Determination
Dogs
Epinephrine
Isoproterenol
Norepinephrine
Old Medline
Phenoxybenzamine
Phenylephrine
Pulmonary Circulation
Sympathetic Nervous System
Sympathomimetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The pulmonary circulatory changes caused by adrenergic drugs using several techniques have been demonstrated by many investigators. The pulmonary arterial pressure and the pulmonary resistance increase with epinephrine, levarterenol and phenylephrine (1-4). Isoproterenol reduces the pulmonary arterial pressure (5, 6). Methoxamine causes either no change in pulmonary arterial pressure (7) or a significant pulmonary hypotension (4, 8). On the other hand, the idea of an adrenergic receptive mechanism was introduced by Langley (9, 10) and the receptor concept was reported by Dale (11) describing two kinds of receptors in the general circulation: receptors having an action resulting in excitation and receptors having an action resulting inhibition of the effector cells. But these two kinds of receptors do not exist in all the places of the body both together, sometimes, only one kind of receptor can be found in some places. We have classified the adrenergic receptors in several organs of the body using several adrenergic drugs and the adrenergic blocking agents (12-16). We have attempted to demonstrate in this paper the kind of adrenergic receptor existing in the pulmonary circulation since no references exist on this problem, even though many investigators have observed the action of adrenergic drugs in the pulmonary circulation, using a limited lung circulation technique and maintaining as normal a circulation as possible.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.13.18