Genetic control of the response of chicken leukocytes to a T-cell mitogen

THE way in which mitogens stimulate lymphocytes to divide in culture is not known. Some mitogens (for example, bacterial lipopolysaccharides) stimulate immunoglobulin-bearing lymphocytes to divide and secrete antibodies; others, such as concavanalin A (con A) or phytohaemagglutinin (PHA), stimulate...

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Bibliographic Details
Published in:Nature (London) 1976-09, Vol.263 (5572), p.61-63
Main Authors: BUDER, A, MIGGIANO, V, NORTH, M, PINK, J. R. L
Format: Article
Language:English
Subjects:
Animals
Chickens
Concanavalin A - pharmacology
DNA - biosynthesis
Genes, Dominant
Genetic Linkage
Histocompatibility Antigens
Humanities and Social Sciences
Lectins - pharmacology
letter
multidisciplinary
Science
Science (multidisciplinary)
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
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Summary:THE way in which mitogens stimulate lymphocytes to divide in culture is not known. Some mitogens (for example, bacterial lipopolysaccharides) stimulate immunoglobulin-bearing lymphocytes to divide and secrete antibodies; others, such as concavanalin A (con A) or phytohaemagglutinin (PHA), stimulate thymus-derived cells (T cells) to proliferate 1,2 . An analysis of the mechanism of action of these mitogens may be helpful in deciding how specific lymphocytes respond to antigen. We report here a case of genetic control of the ability of leukocytes to respond to a T-cell mitogen; lymphocytes from certain inbred chicken lines give a high proliferative response to con A, whereas those of other lines give a low response. The chicken provides a suitable model for studying such responses, in particular because it is easy to culture avian peripheral blood leukocytes and thus compare the results of mitogen stimulation directly with those obtained using human peripheral blood cells.
ISSN:0028-0836
1476-4687
DOI:10.1038/263061a0