Secretory and Motor Effects in the Submaxillary Gland of the Rat on Intraarterial Administration of Some Polypeptides and Autonomic Drugs

Bradykinin, oxytocin, physalaemin and some autonomic drugs were injected into the common carotid artery. Physalaemin evoked secretion and a pressure rise in the submaxillary duct. A duct pressure rise could be elicited by bradykinin which did not evoke secretion. Autonomic blocking agents did not di...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1976-07, Vol.97 (3), p.343-348
Main Author: Thulin, Anders
Format: Article
Language:English
Subjects:
Animals
Bradykinin - administration & dosage
Bradykinin - pharmacology
Epinephrine - administration & dosage
Epinephrine - pharmacology
Injections, Intra-Arterial
Isoproterenol - administration & dosage
Isoproterenol - pharmacology
Kinins - pharmacology
Methacholine Compounds - administration & dosage
Methacholine Compounds - pharmacology
motor effects
Oxytocin - administration & dosage
Oxytocin - pharmacology
Peptides - administration & dosage
Peptides - pharmacology
polypeptides
Pressure
rat
Rats
Saliva - secretion
salivary glands
secretion
Secretory Rate - drug effects
Submandibular Gland - drug effects
Submandibular Gland - secretion
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Summary:Bradykinin, oxytocin, physalaemin and some autonomic drugs were injected into the common carotid artery. Physalaemin evoked secretion and a pressure rise in the submaxillary duct. A duct pressure rise could be elicited by bradykinin which did not evoke secretion. Autonomic blocking agents did not diminish secretion evoked by physalaemin and did not change pressure responses elicited by bradykinin or physalaemin. Neither secretion, nor duct pressure changes could be recorded after administration of oxytocin. In agreement with previous experiments secretion evoked by autonomic drugs was found to be mediated via cholinergic, α‐ and β‐adrenergic receptors, while motor effects were due to activation of cholinergic and a‐adrenergic receptors.
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1976.tb10272.x