Phosphaturia in thalassemia

Thirteen phosphorus balances were performed in four thalassemic children aged 6 to 10 years. No correlation was found between phosphorus intake and serum level or between phosphorus intake and net absorption. There was a positive correlation among daily phosphorus intake, net absorption, and 24-hour...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1976-12, Vol.58 (6), p.885-892
Main Authors: Lapatsanis, P, Sbyrakis, S, Vertos, C, Karaklis, B A, Dosiadis, S
Format: Article
Language:English
Subjects:
Adolescent
Alkaline Phosphatase - blood
Child
Child, Preschool
Hemoglobins - analysis
Humans
Phosphorus - metabolism
Phosphorus - urine
Thalassemia - metabolism
Thalassemia - urine
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Summary:Thirteen phosphorus balances were performed in four thalassemic children aged 6 to 10 years. No correlation was found between phosphorus intake and serum level or between phosphorus intake and net absorption. There was a positive correlation among daily phosphorus intake, net absorption, and 24-hour urinary excretion. The 24-hour urinary excretion level was higher than net absorption, indicating that these children have normal phosphorus absorption but abnormally high renal phosphaturia, which leads to a deficiency of phosphorus. A strongly positive correlation was found between values for hemoglobin and serum alkaline phosphatase. In the thalassemic patients with hemoglobin levels larger than or equal to 7.5 gm/100 ml, the serum alkaline phosphatase values were larger than or equal to 15 King-Armstrong units, suggesting normal osteoblast function.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.58.6.885