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Dihydroergotoxine: Separation and Determination of Four Components by High-Performance Liquid Chromatography
The evaluation of a new high-performance liquid chromatographic method is described. It permits the separation and determination of the four components of dihydroergotoxine (dihydroergocristine, dihydroergocornine, dihydro-α-ergocryptine, and dihydro-β-ergocryp-tine) in a single step. On reversed-ph...
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| Published in: | Journal of pharmaceutical sciences 1978-01, Vol.67 (1), p.98-103 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3415-84a38c2beb61d8b6832ccf3b62f3f947f054bdfafe431181571b45afbab21f523 |
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| cites | cdi_FETCH-LOGICAL-c3415-84a38c2beb61d8b6832ccf3b62f3f947f054bdfafe431181571b45afbab21f523 |
| container_end_page | 103 |
| container_issue | 1 |
| container_start_page | 98 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 67 |
| creator | Hartmann, V. Rödiger, M. Ableidinger, W. Bethke, H. |
| description | The evaluation of a new high-performance liquid chromatographic method is described. It permits the separation and determination of the four components of dihydroergotoxine (dihydroergocristine, dihydroergocornine, dihydro-α-ergocryptine, and dihydro-β-ergocryp-tine) in a single step. On reversed-phase microparticles, complete baseline separation is possible with different mobile phases containing about 10–2M base. The analysis of dihydroergotoxine mesylate drug substance or its dosage forms can be carried out in about 15min. No reference substance is required for the determination of the proportions of the components. This method is simple and exhibits high accuracy, reproducibility, and selectivity. It permits the analytical control of dosage forms containing dihydroergotoxine mesylate to ensure that they comply with the specifications for the drug substance used in clinical and pharmacological studies. |
| doi_str_mv | 10.1002/jps.2600670125 |
| format | article |
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It permits the separation and determination of the four components of dihydroergotoxine (dihydroergocristine, dihydroergocornine, dihydro-α-ergocryptine, and dihydro-β-ergocryp-tine) in a single step. On reversed-phase microparticles, complete baseline separation is possible with different mobile phases containing about 10–2M base. The analysis of dihydroergotoxine mesylate drug substance or its dosage forms can be carried out in about 15min. No reference substance is required for the determination of the proportions of the components. This method is simple and exhibits high accuracy, reproducibility, and selectivity. It permits the analytical control of dosage forms containing dihydroergotoxine mesylate to ensure that they comply with the specifications for the drug substance used in clinical and pharmacological studies.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600670125</identifier><identifier>PMID: 412946</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Antiadrenergic agents-dihydroergotoxine ; Antiadrenergic agents—dihydroergotoxine high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; Dihydroergotoxine - analysis ; Dihydroergotoxine - isolation & purification ; Dihydroergotoxine-high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations ; four components of dihydroergotoxine in bulk drug and pharmaceutical formulations ; high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations ; High-performance liquid chromatography-analyses ; High-performance liquid chromatography—analyses four components of dihydroergotoxine in bulk drug and pharmaceutical formulations ; Solutions - analysis ; Tablets - analysis</subject><ispartof>Journal of pharmaceutical sciences, 1978-01, Vol.67 (1), p.98-103</ispartof><rights>1978 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3415-84a38c2beb61d8b6832ccf3b62f3f947f054bdfafe431181571b45afbab21f523</citedby><cites>FETCH-LOGICAL-c3415-84a38c2beb61d8b6832ccf3b62f3f947f054bdfafe431181571b45afbab21f523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600670125$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600670125$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/412946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hartmann, V.</creatorcontrib><creatorcontrib>Rödiger, M.</creatorcontrib><creatorcontrib>Ableidinger, W.</creatorcontrib><creatorcontrib>Bethke, H.</creatorcontrib><title>Dihydroergotoxine: Separation and Determination of Four Components by High-Performance Liquid Chromatography</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The evaluation of a new high-performance liquid chromatographic method is described. It permits the separation and determination of the four components of dihydroergotoxine (dihydroergocristine, dihydroergocornine, dihydro-α-ergocryptine, and dihydro-β-ergocryp-tine) in a single step. On reversed-phase microparticles, complete baseline separation is possible with different mobile phases containing about 10–2M base. The analysis of dihydroergotoxine mesylate drug substance or its dosage forms can be carried out in about 15min. No reference substance is required for the determination of the proportions of the components. This method is simple and exhibits high accuracy, reproducibility, and selectivity. It permits the analytical control of dosage forms containing dihydroergotoxine mesylate to ensure that they comply with the specifications for the drug substance used in clinical and pharmacological studies.</description><subject>Antiadrenergic agents-dihydroergotoxine</subject><subject>Antiadrenergic agents—dihydroergotoxine high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dihydroergotoxine - analysis</subject><subject>Dihydroergotoxine - isolation & purification</subject><subject>Dihydroergotoxine-high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations</subject><subject>four components of dihydroergotoxine in bulk drug and pharmaceutical formulations</subject><subject>high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations</subject><subject>High-performance liquid chromatography-analyses</subject><subject>High-performance liquid chromatography—analyses four components of dihydroergotoxine in bulk drug and pharmaceutical formulations</subject><subject>Solutions - analysis</subject><subject>Tablets - analysis</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><recordid>eNqFkEtv1DAURi3EayhsWbHIqrsMfsSOhx2aMm1hVAaVh8TGspPrGZckTu2ENv8eo1RFLBCrK917vk-6B6GXBC8JxvT1VR-XVGAsSkwof4AWhFOcC0zKh2iRAJozXqyeomcxXuGEYc6foMcFoatCLFBz4g5THTyEvR_8revgTXYJvQ56cL7LdFdnJzBAaF03b7zNNn4M2dq3ve-gG2JmpuzM7Q_5DoL1odVdBdnWXY-uztaH4Fs9-H3Q_WF6jh5Z3UR4cTeP0JfNu8_rs3z78fR8_XabV6wgPJeFZrKiBowgtTRCMlpVlhlBLbOrorSYF6a22kLBCJGEl8QUXFujDSWWU3aEjufePvjrEeKgWhcraBrdgR-jkqyUkrEygcsZrIKPMYBVfXCtDpMiWP22q5Jd9cduCry6ax5NC_U9PutM59V8vnENTP8pU-93l39V53PWxQFu77M6_FCiZCVX3y5O1eb7p52QXy_Uh8TLmYdk8qeDoGLlILmvXYBqULV3__riFxzaqkA</recordid><startdate>197801</startdate><enddate>197801</enddate><creator>Hartmann, V.</creator><creator>Rödiger, M.</creator><creator>Ableidinger, W.</creator><creator>Bethke, H.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197801</creationdate><title>Dihydroergotoxine: Separation and Determination of Four Components by High-Performance Liquid Chromatography</title><author>Hartmann, V. ; Rödiger, M. ; Ableidinger, W. ; Bethke, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3415-84a38c2beb61d8b6832ccf3b62f3f947f054bdfafe431181571b45afbab21f523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Antiadrenergic agents-dihydroergotoxine</topic><topic>Antiadrenergic agents—dihydroergotoxine high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dihydroergotoxine - analysis</topic><topic>Dihydroergotoxine - isolation & purification</topic><topic>Dihydroergotoxine-high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations</topic><topic>four components of dihydroergotoxine in bulk drug and pharmaceutical formulations</topic><topic>high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations</topic><topic>High-performance liquid chromatography-analyses</topic><topic>High-performance liquid chromatography—analyses four components of dihydroergotoxine in bulk drug and pharmaceutical formulations</topic><topic>Solutions - analysis</topic><topic>Tablets - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hartmann, V.</creatorcontrib><creatorcontrib>Rödiger, M.</creatorcontrib><creatorcontrib>Ableidinger, W.</creatorcontrib><creatorcontrib>Bethke, H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hartmann, V.</au><au>Rödiger, M.</au><au>Ableidinger, W.</au><au>Bethke, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dihydroergotoxine: Separation and Determination of Four Components by High-Performance Liquid Chromatography</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1978-01</date><risdate>1978</risdate><volume>67</volume><issue>1</issue><spage>98</spage><epage>103</epage><pages>98-103</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The evaluation of a new high-performance liquid chromatographic method is described. It permits the separation and determination of the four components of dihydroergotoxine (dihydroergocristine, dihydroergocornine, dihydro-α-ergocryptine, and dihydro-β-ergocryp-tine) in a single step. On reversed-phase microparticles, complete baseline separation is possible with different mobile phases containing about 10–2M base. The analysis of dihydroergotoxine mesylate drug substance or its dosage forms can be carried out in about 15min. No reference substance is required for the determination of the proportions of the components. This method is simple and exhibits high accuracy, reproducibility, and selectivity. It permits the analytical control of dosage forms containing dihydroergotoxine mesylate to ensure that they comply with the specifications for the drug substance used in clinical and pharmacological studies.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>412946</pmid><doi>10.1002/jps.2600670125</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1978-01, Vol.67 (1), p.98-103 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83788337 |
| source | Wiley Online Library - AutoHoldings Journals |
| subjects | Antiadrenergic agents-dihydroergotoxine Antiadrenergic agents—dihydroergotoxine high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Dihydroergotoxine - analysis Dihydroergotoxine - isolation & purification Dihydroergotoxine-high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations four components of dihydroergotoxine in bulk drug and pharmaceutical formulations high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations High-performance liquid chromatography-analyses High-performance liquid chromatography—analyses four components of dihydroergotoxine in bulk drug and pharmaceutical formulations Solutions - analysis Tablets - analysis |
| title | Dihydroergotoxine: Separation and Determination of Four Components by High-Performance Liquid Chromatography |
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