Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease

To date, there is no accepted clinical diagnostic test for Parkinson disease (PD) that is based on biochemical analysis of blood or CSF. The discovery of mutations in the SNCA gene encoding α-synuclein in familial parkinsonism and the accumulation of α-synuclein in the PD brain suggested a critical...

Full description

Saved in:
Bibliographic Details
Published in:Neurology 2010-11, Vol.75 (20), p.1766-1770
Main Authors: Tokuda, T., Qureshi, M.M., Ardah, M.T., Varghese, S., Shehab, S.A.S., Kasai, T., Ishigami, N., Tamaoka, A., Nakagawa, M., El-Agnaf, O.M.A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
alpha-Synuclein - cerebrospinal fluid
alpha-Synuclein - chemistry
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - diagnosis
Alzheimer Disease - metabolism
Biological and medical sciences
Biomarkers - cerebrospinal fluid
Biomarkers - chemistry
Brain Chemistry
Cohort Studies
Cross-Sectional Studies - methods
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Medical sciences
Middle Aged
Neurology
Parkinson Disease - cerebrospinal fluid
Parkinson Disease - diagnosis
Parkinson Disease - metabolism
Pilot Projects
Supranuclear Palsy, Progressive - cerebrospinal fluid
Supranuclear Palsy, Progressive - diagnosis
Supranuclear Palsy, Progressive - metabolism
Up-Regulation - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!