The Normal Development of the Lymphoid Mass in the Golden Hamster and its Relationship to the Effects of Thymectomy

A study of lymphoid organ sections and imprints of normal hamsters from fetal to adult state revealed a sequential pattern of organ structure and growth. The thymus developed an adult structure by 1 week, maximum size at 6 weeks. The mesenteric lymph node had an adult structure by 4 weeks, the splee...

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Bibliographic Details
Published in:Blood 1965-04, Vol.25 (4), p.511-521
Main Authors: M. Adner, Marvin, D. Sherman, Joseph, Dameshek, William
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Cricetinae
Fetus
Graft vs Host Disease
Growth
Hematopoiesis
Histology
Immune Tolerance
Lymph Nodes
Mesocricetus
Old Medline
Organ Size
Spleen
Thymectomy
Thymus Gland
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Summary:A study of lymphoid organ sections and imprints of normal hamsters from fetal to adult state revealed a sequential pattern of organ structure and growth. The thymus developed an adult structure by 1 week, maximum size at 6 weeks. The mesenteric lymph node had an adult structure by 4 weeks, the spleen by 6 weeks, with an accelerated growth of both organs between 6 to 8 weeks. The growth and development of the peripheral lymphoid organs appears to be under thymic control until the attainment of a "critical peripheral lymphoid mass." This appears capable of functioning independently of thymic control. Thymectomy is effective in producing lymphoid atrophy with resultant immunosuppression and wasting disease only if performed prior to the attainment of the "critical peripheral lymphoid mass."
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V25.4.511.511