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Hepatic Binding Protein: The Protective Role of Its Sialic Acid Residues
Removal of sialic acid from a specific hepatic binding protein virtually abolishes its capacity to bind certain asialoglycoproteins. The loss of this capacity is the result of competition for the binding sites by galactosyl residues, of hepatic binding protein, that become terminal after desialylati...
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| Published in: | Science (American Association for the Advancement of Science) 1977-08, Vol.197 (4304), p.667-668 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c340t-289bc79a5fd18a4e4446d3b5e3ba40759bbcab2e73e4deee55f6a2df8de493ee3 |
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| cites | cdi_FETCH-LOGICAL-c340t-289bc79a5fd18a4e4446d3b5e3ba40759bbcab2e73e4deee55f6a2df8de493ee3 |
| container_end_page | 668 |
| container_issue | 4304 |
| container_start_page | 667 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 197 |
| creator | Stockert, Richard J. Morell, Anatol G. Scheinberg, I. Herbert |
| description | Removal of sialic acid from a specific hepatic binding protein virtually abolishes its capacity to bind certain asialoglycoproteins. The loss of this capacity is the result of competition for the binding sites by galactosyl residues, of hepatic binding protein, that become terminal after desialylation. |
| doi_str_mv | 10.1126/science.877581 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1977-08, Vol.197 (4304), p.667-668 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83991836 |
| source | American Association for the Advancement of Science |
| subjects | Acetylgalactosamine - metabolism Amino acids Asialoglycoproteins Binding Sites Blood plasma Carrier proteins Carrier Proteins - metabolism Coal Coumaric acids Glycoproteins Glycoproteins - metabolism Liver - metabolism Membrane Proteins - metabolism Mucins - metabolism Orosomucoid - metabolism Pyrites Sialic Acids - metabolism Structure-Activity Relationship Sulfur |
| title | Hepatic Binding Protein: The Protective Role of Its Sialic Acid Residues |
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