Thrombocytopenia Inherited as an Autosomal Dominant Trait

IN CONTRAST to the hereditary disorders of red cells and white cells, inherited disorders of the platelets appear to be rare. Among the few reports of hereditary thrombocytopenia,1-14some lack essential history or supporting laboratory data. Those which present more convincing evidence display a rem...

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Bibliographic Details
Published in:Blood 1965-02, Vol.25 (2), p.231-240
Main Authors: Bithell, T.C, P, Didisheim, G.E, Cartwright, M.M, Wintrobe
Format: Article
Language:English
Subjects:
Blood Platelet Disorders
Genetics, Medical
Hemorrhagic Disorders
Humans
Old Medline
Thrombocytopenia
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Summary:IN CONTRAST to the hereditary disorders of red cells and white cells, inherited disorders of the platelets appear to be rare. Among the few reports of hereditary thrombocytopenia,1-14some lack essential history or supporting laboratory data. Those which present more convincing evidence display a remarkable variety of clinical features and genetic patterns. Only the so-called Aldrich syndrome7 emerges as a definite clinical and genetic entity. This report concerns a family of eight members of a kindred in which four generations have been afflicted with a hemorrhagic diathesis which appears to be the result of mild thrombocytopenia inherited as an autosomal dominant trait.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V25.2.231.231