The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance

The induction and maintenance of T-cell tolerance to tissue antigens is essential to prevent autoimmunity. Combinations of central and peripheral mechanisms act in parallel to inactivated, eliminated or control autoreactive T cells. Both centrally and peripherally, a key requirement for self-toleran...

Full description

Saved in:
Bibliographic Details
Published in:Autoimmunity (Chur, Switzerland) Switzerland), 2011-02, Vol.44 (1), p.23-32
Main Authors: Zanoni, Ivan, Granucci, Francesca
Format: Article
Language:English
Subjects:
Autoantigens - immunology
Autoimmune Diseases - immunology
Autoimmunity
Cytokines
dendritic cells
Dendritic Cells - immunology
Dendritic Cells - metabolism
Humans
Interleukin-2
regulatory T cells
Self Tolerance
T-Lymphocytes - immunology
tolerance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The induction and maintenance of T-cell tolerance to tissue antigens is essential to prevent autoimmunity. Combinations of central and peripheral mechanisms act in parallel to inactivated, eliminated or control autoreactive T cells. Both centrally and peripherally, a key requirement for self-tolerance is the presentation of self-antigens in a correct context. There is now evidence to suggest that dendritic cells (DCs) play a fundamental role in the development of central and peripheral tolerance. In this review, we summarize recent progress toward the definition of the multiple roles of DCs in these processes. We will also discuss the association between defects in the DC compartment and the development of autoimmune responses, with particular reference to DC deregulation in the context of type I diabetes.
ISSN:0891-6934
1607-842X
DOI:10.3109/08916931003782148