Model System for Study of Artificially Induced Resistance to Malaria

THERE is still a pressing need for a vaccination model against malarial infection 1 . The laboratory rodent has been vigorously studied for this purpose since the discovery of Plasmodium berghei more than 20 yr ago 2 . Of recent reports describing various methods for the induction of resistance to m...

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Bibliographic Details
Published in:Nature (London) 1969-08, Vol.223 (5205), p.507-509
Main Authors: D'ANTONIO, LAWRENCE E, SPIRA, DAN T, SILVERMAN, PAUL H
Format: Article
Language:English
Subjects:
Age Factors
Animals
Erythrocyte Count
Humanities and Social Sciences
Injections, Intraperitoneal
Injections, Subcutaneous
letter
Malaria - prevention & control
Mice
Models, Biological
multidisciplinary
Plasmodium - pathogenicity
Science
Science (multidisciplinary)
Vaccination
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Summary:THERE is still a pressing need for a vaccination model against malarial infection 1 . The laboratory rodent has been vigorously studied for this purpose since the discovery of Plasmodium berghei more than 20 yr ago 2 . Of recent reports describing various methods for the induction of resistance to malaria 3–5 , none have reported good success utilizing non-viable blood stage plasmodial material. The rat has been only partially responsive to such material, while the mouse has remained uniformly refractory 6 .
ISSN:0028-0836
1476-4687
DOI:10.1038/223507a0