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Model System for Study of Artificially Induced Resistance to Malaria
THERE is still a pressing need for a vaccination model against malarial infection 1 . The laboratory rodent has been vigorously studied for this purpose since the discovery of Plasmodium berghei more than 20 yr ago 2 . Of recent reports describing various methods for the induction of resistance to m...
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| Published in: | Nature (London) 1969-08, Vol.223 (5205), p.507-509 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c335t-b4d3f7e800ea2dac3ad8057728a7ac8f84ab337e56ad2546561a75120efedb473 |
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| cites | cdi_FETCH-LOGICAL-c335t-b4d3f7e800ea2dac3ad8057728a7ac8f84ab337e56ad2546561a75120efedb473 |
| container_end_page | 509 |
| container_issue | 5205 |
| container_start_page | 507 |
| container_title | Nature (London) |
| container_volume | 223 |
| creator | D'ANTONIO, LAWRENCE E SPIRA, DAN T SILVERMAN, PAUL H |
| description | THERE is still a pressing need for a vaccination model against malarial infection
1
. The laboratory rodent has been vigorously studied for this purpose since the discovery of
Plasmodium berghei
more than 20 yr ago
2
. Of recent reports describing various methods for the induction of resistance to malaria
3–5
, none have reported good success utilizing non-viable blood stage plasmodial material. The rat has been only partially responsive to such material, while the mouse has remained uniformly refractory
6
. |
| doi_str_mv | 10.1038/223507a0 |
| format | article |
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1
. The laboratory rodent has been vigorously studied for this purpose since the discovery of
Plasmodium berghei
more than 20 yr ago
2
. Of recent reports describing various methods for the induction of resistance to malaria
3–5
, none have reported good success utilizing non-viable blood stage plasmodial material. The rat has been only partially responsive to such material, while the mouse has remained uniformly refractory
6
.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/223507a0</identifier><identifier>PMID: 5796953</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Age Factors ; Animals ; Erythrocyte Count ; Humanities and Social Sciences ; Injections, Intraperitoneal ; Injections, Subcutaneous ; letter ; Malaria - prevention & control ; Mice ; Models, Biological ; multidisciplinary ; Plasmodium - pathogenicity ; Science ; Science (multidisciplinary) ; Vaccination</subject><ispartof>Nature (London), 1969-08, Vol.223 (5205), p.507-509</ispartof><rights>Springer Nature Limited 1969</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-b4d3f7e800ea2dac3ad8057728a7ac8f84ab337e56ad2546561a75120efedb473</citedby><cites>FETCH-LOGICAL-c335t-b4d3f7e800ea2dac3ad8057728a7ac8f84ab337e56ad2546561a75120efedb473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2725,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5796953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D'ANTONIO, LAWRENCE E</creatorcontrib><creatorcontrib>SPIRA, DAN T</creatorcontrib><creatorcontrib>SILVERMAN, PAUL H</creatorcontrib><title>Model System for Study of Artificially Induced Resistance to Malaria</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>THERE is still a pressing need for a vaccination model against malarial infection
1
. The laboratory rodent has been vigorously studied for this purpose since the discovery of
Plasmodium berghei
more than 20 yr ago
2
. Of recent reports describing various methods for the induction of resistance to malaria
3–5
, none have reported good success utilizing non-viable blood stage plasmodial material. The rat has been only partially responsive to such material, while the mouse has remained uniformly refractory
6
.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Erythrocyte Count</subject><subject>Humanities and Social Sciences</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Subcutaneous</subject><subject>letter</subject><subject>Malaria - prevention & control</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>multidisciplinary</subject><subject>Plasmodium - pathogenicity</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Vaccination</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><recordid>eNptkM9LwzAYhoMoc07Bf0DJSfRQTZqmyY5j_hpsCE7P5WvyRTq6dibtof-9lc6dPL2H9-GB9yXkkrN7zoR-iGMhmQJ2RMY8UWmUpFodkzFjsY6YFukpOQthwxiTXCUjMpJqmk6lGJPHVW2xpOsuNLilrvZ03bS2o7WjM98UrjAFlGVHF5VtDVr6jqEIDVQGaVPTFZTgCzgnJw7KgBf7nJDP56eP-Wu0fHtZzGfLyAghmyhPrHAKNWMIsQUjwGomlYo1KDDa6QRyIRTKFGwsk1SmHJTkMUOHNk-UmJCbwbvz9XeLocm2RTBYllBh3YZMJzyd9tN78HYAja9D8OiynS-24LuMs-z3sOzvsB692jvbfIv2AO4f6vu7oQ99U32hzzZ166t-5n-u64GtoGk9HlwH4AcrC3vy</recordid><startdate>19690802</startdate><enddate>19690802</enddate><creator>D'ANTONIO, LAWRENCE E</creator><creator>SPIRA, DAN T</creator><creator>SILVERMAN, PAUL H</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19690802</creationdate><title>Model System for Study of Artificially Induced Resistance to Malaria</title><author>D'ANTONIO, LAWRENCE E ; SPIRA, DAN T ; SILVERMAN, PAUL H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-b4d3f7e800ea2dac3ad8057728a7ac8f84ab337e56ad2546561a75120efedb473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Erythrocyte Count</topic><topic>Humanities and Social Sciences</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Subcutaneous</topic><topic>letter</topic><topic>Malaria - prevention & control</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>multidisciplinary</topic><topic>Plasmodium - pathogenicity</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D'ANTONIO, LAWRENCE E</creatorcontrib><creatorcontrib>SPIRA, DAN T</creatorcontrib><creatorcontrib>SILVERMAN, PAUL H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D'ANTONIO, LAWRENCE E</au><au>SPIRA, DAN T</au><au>SILVERMAN, PAUL H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Model System for Study of Artificially Induced Resistance to Malaria</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1969-08-02</date><risdate>1969</risdate><volume>223</volume><issue>5205</issue><spage>507</spage><epage>509</epage><pages>507-509</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>THERE is still a pressing need for a vaccination model against malarial infection
1
. The laboratory rodent has been vigorously studied for this purpose since the discovery of
Plasmodium berghei
more than 20 yr ago
2
. Of recent reports describing various methods for the induction of resistance to malaria
3–5
, none have reported good success utilizing non-viable blood stage plasmodial material. The rat has been only partially responsive to such material, while the mouse has remained uniformly refractory
6
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>5796953</pmid><doi>10.1038/223507a0</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1969-08, Vol.223 (5205), p.507-509 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84169468 |
| source | Single Title from Nature Journals |
| subjects | Age Factors Animals Erythrocyte Count Humanities and Social Sciences Injections, Intraperitoneal Injections, Subcutaneous letter Malaria - prevention & control Mice Models, Biological multidisciplinary Plasmodium - pathogenicity Science Science (multidisciplinary) Vaccination |
| title | Model System for Study of Artificially Induced Resistance to Malaria |
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