Metabolism of dl-Lysine-2- and -6-14C in Rats and Dogs

Liver, carcass (rat), and plasma (dog) glutamic and aspartic acids have been isolated from rats and dogs given lysine-2- or -6- 14 C. In some instances considerable non-carboxyl labeling was observed in glutamate and aspartate, presumably resulting from lysine catabolism by intestinal flora. Lysine-...

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Bibliographic Details
Published in:The Journal of biological chemistry 1966-06, Vol.241 (11), p.2622-2625
Main Authors: Meghal, S K, Cheung, H S, O'Neal, R M, Koeppe, R E
Format: Article
Language:English
Subjects:
Animals
Aspartic Acid - biosynthesis
Aspartic Acid - blood
Carbon Isotopes - metabolism
Dogs
Glutamates - biosynthesis
Glutamates - blood
Liver - analysis
Lysine - metabolism
Rats
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Summary:Liver, carcass (rat), and plasma (dog) glutamic and aspartic acids have been isolated from rats and dogs given lysine-2- or -6- 14 C. In some instances considerable non-carboxyl labeling was observed in glutamate and aspartate, presumably resulting from lysine catabolism by intestinal flora. Lysine-6- 14 C yielded tissue glutamate labeled predominantly in carbon 1, and lysine-2- 14 C yielded tissue glutamate labeled predominantly in carbon 5. These results indicate that during the mammalian catabolism of lysine, glutaryl coenzyme A, but not free glutaric acid, is a major intermediate.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)96585-3