Methionine deficiency and iron retention in the rat

1. Methionine-deficient diets were given to rats for 4 weeks. 2. This resulted in a decrease in total body iron, due to a decrease either in Fe absorption or Fe retention. 3. There was inhibition of growth, development of anaemia and a shift of body Fe to the liver. 4. There were no histological alt...

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Bibliographic Details
Published in:British journal of nutrition 1966-01, Vol.20 (4), p.813-817
Main Authors: Kaufman, Nathan, Klavins, Janis V., Kinney, Thomas D.
Format: Article
Language:English
Subjects:
Anemia - etiology
Animals
Blood Glucose - analysis
Body Weight
Deficiency Diseases - metabolism
Hematocrit
Hemoglobinometry
Iron - metabolism
Liver - metabolism
Methionine - metabolism
Pancreatic Diseases - etiology
Rats
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Summary:1. Methionine-deficient diets were given to rats for 4 weeks. 2. This resulted in a decrease in total body iron, due to a decrease either in Fe absorption or Fe retention. 3. There was inhibition of growth, development of anaemia and a shift of body Fe to the liver. 4. There were no histological alterations which could be interpreted as specific to methionine deficiency. 5. These findings were different from reports of effects of ethionine in which there is an increased Fe absorption and various tissue alterations, including pancreatic acinar and liver damage.
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN19660083