Cyclic Methyldopa Analogs as Potential Antihypertensive and Antineoplastic Agents

Three cyclic methyldopa analogs (IIIa, b, and c) were synthesized by hydrolysis of the appropriate spirohydantoins (V), which were obtained through the Bucherer synthesis. Amino acids (IIIa and b) and hydantoins (Va and c) were inactive against experimental tumors. The 5 hydantoins tested were devoi...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1966-04, Vol.55 (4), p.443-445
Main Authors: Burckhalter, J.H., Schmied, Günter
Format: Article
Language:English
Subjects:
Animals
Chromatography, Paper
Chromatography, Thin Layer
Hydantoins - therapeutic use
Infrared Rays
Leukemia L1210 - drug therapy
Methyldopa - therapeutic use
Neoplasms, Experimental - drug therapy
Sarcoma 180 - drug therapy
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Summary:Three cyclic methyldopa analogs (IIIa, b, and c) were synthesized by hydrolysis of the appropriate spirohydantoins (V), which were obtained through the Bucherer synthesis. Amino acids (IIIa and b) and hydantoins (Va and c) were inactive against experimental tumors. The 5 hydantoins tested were devoid of anticonvulsant effect.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600550423