Cytochrome c in Normal and Hypertrophied Heart

THE high cytochrome c content of the heart reflects the striking capacity of this organ for oxidative phosphorylation 1,2 . In 1956, Biörck 3 studied the concentration of cytochrome c in human hearts obtained at autopsy. He found that in children and adults the concentration of this haemoprotein in...

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Bibliographic Details
Published in:Nature (London) 1966-11, Vol.212 (5062), p.608-609
Main Author: DALLMAN, P. R
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Cardiomegaly - metabolism
Child
Child, Preschool
Cytochromes - analysis
Heart Ventricles - analysis
Humanities and Social Sciences
Humans
Infant
Infant, Newborn
letter
multidisciplinary
Myocardium - analysis
Science
Swine
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Summary:THE high cytochrome c content of the heart reflects the striking capacity of this organ for oxidative phosphorylation 1,2 . In 1956, Biörck 3 studied the concentration of cytochrome c in human hearts obtained at autopsy. He found that in children and adults the concentration of this haemoprotein in the left ventricle exceeded that in the corresponding right chamber except in two cases of pulmonary hypertension with right ventricular hypertrophy. It was suggested that the elevation of cytochrome c with right ventricular hypertrophy might reflect a metabolic response to increased work load. In the case of skeletal muscle, it was previously recognized that chronic exercise load is associated with increased respiratory enzyme activity per unit of muscle mass 4 . In order to confirm and extend the observations of Biörck in heart muscle, the present study compared left and right ventricular concentrations of cytochrome c under conditions of normal and abnormal changes in cardiac function. Foetal and newborn human hearts, which normally have right hypertrophy, and hypertrophied hearts with congenital lesions were studied. Normal hearts from foetal, newborn, and adult pigs were also utilized.
ISSN:0028-0836
1476-4687
DOI:10.1038/212608a0