Role of core needle biopsy and ultrasonographic finding in management of indeterminate thyroid nodules

Background Thyroid fine‐needle aspiration (FNA) is used as a screening test of choice for evaluation of thyroid nodules. However, approximately 15% to 25% of the cases are classified as indeterminate, posing dilemmas in decision‐making. This study was designed to compare the diagnostic performances...

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Bibliographic Details
Published in:Head & neck 2011-02, Vol.33 (2), p.160-165
Main Authors: Park, Kyung Tae, Ahn, Soon-Hyun, Mo, Ji-Hun, Park, Young Joo, Park, Do Joong, Choi, Sang Il, Park, So-Yeon
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biopsy, Fine-Needle
Biopsy, Needle - methods
core needle biopsy
Diagnosis, Differential
Endocrinopathies
Female
fine-needle biopsy
Humans
indeterminate
Male
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Otorhinolaryngology. Stomatology
papillary carcinoma
Predictive Value of Tests
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - pathology
thyroid nodule
Thyroid Nodule - diagnostic imaging
Thyroid Nodule - pathology
Thyroid Nodule - surgery
Thyroid. Thyroid axis (diseases)
Treatment Outcome
Ultrasonography
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Summary:Background Thyroid fine‐needle aspiration (FNA) is used as a screening test of choice for evaluation of thyroid nodules. However, approximately 15% to 25% of the cases are classified as indeterminate, posing dilemmas in decision‐making. This study was designed to compare the diagnostic performances of second FNA and core needle biopsy of indeterminate nodules by initial FNA. Methods From February 2005 through June 2009, 258 patients who completed scheduled follow‐ups were enrolled and the follow‐up results were analyzed. Results Nondiagnostic results were obtained in 41.8% of the second FNA group and in 1.7% of the core needle biopsy group (p < .001; chi‐square). The nodules that show borderline features in preoperative ultrasonography had a malignancy rate of 18.3% and could be identified successfully with core needle biopsy. Conclusion Core needle biopsy is a better method for evaluating indeterminate nodules by initial FNA than second FNA, especially in patients with ultrasonographic findings of a borderline nodule. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.21414