Pulmonary Arterial Pulse Wave Velocity and Impedance in Man

The differential pressure method of Womersley and McDonald was used to measure instantaneous blood flow in the main pulmonary artery in ten human subjects. Three subjects had normal pulmonary arterial pressures and flows, seven had mitral stenosis and pulmonary hypertension. The spectrum of input im...

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Bibliographic Details
Published in:Circulation research 1969-12, Vol.25 (6), p.637-649
Main Authors: Milnor, William R, Conti, C Richard, Lewis, Kenneth B, OʼRourke, Michael F
Format: Article
Language:English
Subjects:
Adult
Arteries
Biophysical Phenomena
Biophysics
Blood Flow Velocity
Capillaries
Elasticity
Female
Hemodynamics
Humans
Hypertension, Pulmonary - physiopathology
Male
Middle Aged
Mitral Valve Stenosis - physiopathology
Pulmonary Artery - physiology
Pulmonary Artery - physiopathology
Pulse
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Summary:The differential pressure method of Womersley and McDonald was used to measure instantaneous blood flow in the main pulmonary artery in ten human subjects. Three subjects had normal pulmonary arterial pressures and flows, seven had mitral stenosis and pulmonary hypertension. The spectrum of input impedance versus frequency was similar to that previously reported for the dog and rabbit, with the modulus decreasing from relatively high values at zero frequency to a minimum between 2 and 5 cycles/sec. Characteristic impedance and phase velocity were lower in the normal subjects than in those with pulmonary hypertension (averages, 23 dyne sec cm and 1.68 m/sec in the normals; 46 dyne sec cm and 4.77 m/sec in the hypertensives). Hydraulic energy dissipated per unit time by pulsations in the pulmonary bed was usually higher in the hypertensive than in the normal cases, because of the greater stiffness of the pulmonary arteries in the subjects with pulmonary hypertension. The elasticity of the pulmonary arterial tree appears to be as important as the state of the arterioles and capillaries in determining the energy required for pulsatile pulmonary blood flow.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.25.6.637