Metabolic Fate of Mineral Oil Adjuvants Using 14C-Labeled Tracers II: Mannide Monooleate

This investigation was undertaken to determine the metabolic fate of mannide monooleate when employed in a mineral oil emulsion. Female white rats and female squirrel monkeys were injected subcutaneously or intramuscularly with an emulsion made with mineral oil and surfactant and including either 1-...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1970-08, Vol.59 (8), p.1088-1092
Main Author: Bollinger, James N.
Format: Article
Language:English
Subjects:
1-14C-Oleate-labeled mannide monooleate-metabolic fate
Adipose Tissue - analysis
Animals
Brain Chemistry
Carbon Isotopes
Chromatography, Thin Layer
Emulsions
Fatty Acids, Nonesterified - analysis
Female
Haplorhini
Injections, Intramuscular
Injections, Subcutaneous
Intestine, Small - analysis
intramuscular injection
Kidney - analysis
Lipids - analysis
Liver - analysis
Lung - analysis
Lymph Nodes - analysis
Metabolic fate-mannide monooleate in mineral oil emulsion
Mineral Oil - metabolism
Mineral oil-mannide monooleate emulsion-subcutaneous
Mineral oil-mannide monooleate emulsion-subcutaneous, intramuscular injection
Oleic Acids - metabolism
Ovary - analysis
Pharmaceutic Aids - metabolism
Rats
Spleen - analysis
Time Factors
TLC-identity
UL-14C-Mannide-labeled mannide monooleate-metabolic fate
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Summary:This investigation was undertaken to determine the metabolic fate of mannide monooleate when employed in a mineral oil emulsion. Female white rats and female squirrel monkeys were injected subcutaneously or intramuscularly with an emulsion made with mineral oil and surfactant and including either 1-14C-oleate or UL-14C-mannide-labeled mannide monooleate tracer preparations. It was shown that 30-40% of the surfactant mixture is removed from the site of injection after 24 hr. After 1 week, 40-60% of the surfactant is removed from the site of injection; while after 3 months, 10-30% of the surfactant still remains. The 1-14C-oleatelabeled mannide monooleate was largely incorporated into the various lipid classes, while the UL-14C-mannide-labeled mannide monooleate preparation was largely eliminated in the urine. There was some indication that the inguinal lymph nodes of monkeys may have contained unusually large amounts of radioactivity.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600590805