Self-reported prevalence of hypersensitivity reactions against drugs among medical students: does awareness cause any difference?

Purpose True epidemiologic data on hypersensitivity reactions to drugs are scarce. More accurate data may be obtained in more specific clinical settings. Considering their educational background, medical students may be an appropriate target audience for evaluating prevalence of drug hypersensitivit...

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Bibliographic Details
Published in:Pharmacoepidemiology and drug safety 2011-02, Vol.20 (2), p.154-161
Main Authors: Bavbek, Sevim, Erkekol, Ferda Öner, Çelik, Gülfem Elif, Gönüllü, İpek, Mısırlıgil, Zeynep
Format: Article
Language:English
Subjects:
Age
Attitude of Health Personnel
Awareness
Chi-Square Distribution
drug allergy
drug hypersensitivity
Drug Hypersensitivity - diagnosis
Drug Hypersensitivity - epidemiology
Drug Hypersensitivity - psychology
Drug Hypersensitivity - therapy
epidemiology
Female
Health Knowledge, Attitudes, Practice
Humans
Logistic Models
Male
medical student
Odds Ratio
Prevalence
Referral and Consultation
Retrospective Studies
Risk Assessment
Risk Factors
Self Report
Students, Medical - psychology
Students, Medical - statistics & numerical data
Surveys and Questionnaires
Turkey - epidemiology
Young Adult
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Summary:Purpose True epidemiologic data on hypersensitivity reactions to drugs are scarce. More accurate data may be obtained in more specific clinical settings. Considering their educational background, medical students may be an appropriate target audience for evaluating prevalence of drug hypersensitivity. This study is designed to determine the prevalence of self‐reported drug hypersensitivity alongside related factors among young adults. Methods A structured questionnaire was administered to the students. Results A total of 1267 students (mean age: 21.71 + 1.90 years, F/M: 648/619) from all grades responded to the survey. The mean prevalence of self‐reported drug hypersensitivity was 4.7% (60/1267). The most frequently involved drugs were beta‐lactam antibiotics (55%) followed by non‐steroidal anti‐inflammatory drugs (28%). The most commonly reported clinical presentations were cutaneous (43.3%), followed by systemic (36.8%), cardiovascular (8.3%) and respiratory (8.3%) symptoms. Factors related with reported reactions were higher grades (p = 0.015, OR: 2.09), female gender (p = 0.006, OR: 2.13), personal history of allergic diseases (p = 0.001, OR: 2.64), and family history of drug hypersensitivity (p 
ISSN:1053-8569
1099-1557
1099-1557
DOI:10.1002/pds.2076