N-aralkyl-N-methylaminoethyl carbanilates as hypocholesteremic agents

A group of aralkylaminoethyl esters and ureas of substituted carbanilic acids was prepared and studied for hypocholesteremic activity in eucholesteremic mice. Biological results indicated that modification of either terminal aromatic ring altered the activity of the resultant compound. The meta and...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences 1967-12, Vol.56 (12), p.1598-1603
Main Authors: Rost, William J., Sutton, Elaine M., Blank, Benjamin, Pfeiffer, Francis R., Holmes, William L., Ditullio, Nicholas W., Ingram, Edwin B.
Format: Article
Language:English
Subjects:
Anilides - chemical synthesis
Anilides - pharmacology
Aniline Compounds - chemical synthesis
Aniline Compounds - pharmacology
Animals
Anticholesteremic Agents - chemical synthesis
Anticholesteremic Agents - pharmacology
Chemical Phenomena
Chemistry, Physical
Cholesterol - blood
Liver - metabolism
Male
Mice
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A group of aralkylaminoethyl esters and ureas of substituted carbanilic acids was prepared and studied for hypocholesteremic activity in eucholesteremic mice. Biological results indicated that modification of either terminal aromatic ring altered the activity of the resultant compound. The meta and para methyl substituted carbanilates of aralkylmethylaminoethanol consistently exhibited the most desirable effect. In the dicarbanilate series of aralkyl or aryl substituted iminodiethanols, no appreciable activity was seen.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600561213