Tissue response to a new type of biomaterial implanted subcutaneously in rats

Introduction and hypothesis A new type of resorbable biomaterial intended for pelvic reconstruction was tested with respect to tissue regeneration and biocompatibility in rats. The biomaterial consisted of methoxypolyethyleneglycol-poly(lactic-co-glycolic acid) (MPEG-PLGA). Implants were pure, enric...

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Bibliographic Details
Published in:International Urogynecology Journal 2011-02, Vol.22 (2), p.191-196
Main Authors: Boennelycke, Marie, Christensen, Lise, Nielsen, Lene Feldskov, Everland, Hanne, Lose, Gunnar
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Biocompatible Materials
Estrogens - pharmacology
Extracellular Matrix
Female
Gynecology
Materials Testing
Medicine
Medicine & Public Health
Original Article
Pelvic Organ Prolapse - surgery
Polyesters - pharmacology
Polyethylene Glycols - pharmacology
Rats
Rats, Sprague-Dawley
Regeneration - drug effects
Urology
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Summary:Introduction and hypothesis A new type of resorbable biomaterial intended for pelvic reconstruction was tested with respect to tissue regeneration and biocompatibility in rats. The biomaterial consisted of methoxypolyethyleneglycol-poly(lactic-co-glycolic acid) (MPEG-PLGA). Implants were pure, enriched with extra-cellular matrix (ECM) or estrogen. Methods Ten implants of each type were tested for 3 and 8 weeks, respectively. Histological assessment of connective tissue organization, inflammation, vascularization, and thickness of regenerated tissue was undertaken. Results All implants had a high degree of biocompatibility. ECM-enriched implants had significantly higher inflammatory scores compared to pure implants at 3 weeks. At 8 weeks, neither of the parameters differed significantly. No trace of the implants remained. Conclusions The MPEG-PLGA is highly biocompatible, degrades quickly, and seems inert in the process of tissue regeneration. Thus, it is hardly a candidate per se in reinforcement of pelvic reconstruction, but it could have a future role as carrier for stem cells.
ISSN:0937-3462
1433-3023
DOI:10.1007/s00192-010-1257-3