Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment

Human papillomavirus (HPV) infection is considered to be the necessary cause of cervical cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant transformation of cervical cells, inhibiting the tumor suppressors p53 and Rb. However, the role of E5 oncoprotein has been...

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Bibliographic Details
Published in:Biochemical pharmacology 2010-12, Vol.80 (12), p.1930-1935
Main Authors: Kim, Mi-Kyung, Kim, Hee Seung, Kim, Su-Hyeong, Oh, Jung-Min, Han, Jae Yong, Lim, Jeong Mook, Juhnn, Yong-Sung, Song, Yong-Sang
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Apoptosis
Biological and medical sciences
Cancer Vaccines - therapeutic use
Cell Proliferation
Cervical cancer
COX-2
EGFR
Female
Female genital diseases
Genetic Therapy
Gynecology. Andrology. Obstetrics
Human papillomavirus
Humans
Infectious diseases
Medical sciences
Molecular Targeted Therapy
Neovascularization, Pathologic - metabolism
Oncogene Proteins, Viral - genetics
Oncogene Proteins, Viral - immunology
Oncogene Proteins, Viral - physiology
Pharmacology. Drug treatments
Receptor, Epidermal Growth Factor - physiology
Signal Transduction
Tumors
Uterine Cervical Neoplasms - blood supply
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - therapy
Viral diseases
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Summary:Human papillomavirus (HPV) infection is considered to be the necessary cause of cervical cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant transformation of cervical cells, inhibiting the tumor suppressors p53 and Rb. However, the role of E5 oncoprotein has been relatively less defined. HPV 16 E5 is a hydrophobic membrane-bound protein which associates with the Golgi apparatus, endoplasmic reticulum and perinuclear membrane. Accumulating evidences have suggested that E5 oncoprotein may also contribute to cervical carcinogenesis through modulating cellular signaling pathways in addition to augmenting the immortalization potential of E6 and E7. Multiple mechanisms, including activation of EGFR or inflammatory cell signaling pathway, have been implicated in malignant transformation by HPV 16 E5. Therefore, targeting E5 may be a rational approach for chemoprevention and treatment of cervical cancer, and understanding its oncogenic processes may help us to design novel therapeutic strategies. In this review, we discussed the roles of HPV 16 E5 in cervical carcinogenesis, altering several cellular signaling pathways involved in cell proliferation, angiogenesis and apoptosis.
ISSN:0006-2952
1873-2968
DOI:10.1016/j.bcp.2010.07.013