Respiration in Myocardium

The q O 2 or oxygen uptake of a tissue is considered to be a reflexion of the metabolic energy produced through substrate catabolism to support its functional activities. It is usually accepted that the total in vivo oxygen consumption is directly related to ATP production as the sole energy transfe...

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Bibliographic Details
Published in:Nature (London) 1968-01, Vol.217 (5123), p.78-79
Main Author: CHALLONER, DAVID R
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Cyanides - pharmacology
Heart Arrest
Humanities and Social Sciences
letter
Male
Mitochondria - metabolism
multidisciplinary
Myocardium - metabolism
Oligomycins - pharmacology
Oxidative Phosphorylation
Oxygen Consumption
Perfusion
Phosphorus Isotopes
Rats
Science
Science (multidisciplinary)
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Summary:The q O 2 or oxygen uptake of a tissue is considered to be a reflexion of the metabolic energy produced through substrate catabolism to support its functional activities. It is usually accepted that the total in vivo oxygen consumption is directly related to ATP production as the sole energy transfer and storage mechanism for endergonic processes 1 . Energy balance calculations in biology make use of this assumption, which is based on the known in vitro efficiencies of these processes. Recently biochemists have shown that certain non-mitochondrial enzyme systems assimilate or “take up” oxygen 2 and that respiration without phosphorylation is probably essential to many of the biological functions of mitochondria 3 . The relative contribution of non-phosphorylating and non-mitochondrial oxygen uptake to total respiration in vivo has been studied in the isolated perfused rat heart. Oligomycin and cyanide were used as inhibitors to distinguish mitochondrial but non-phosphorylating respiration from non-mitochondrial respiration.
ISSN:0028-0836
1476-4687
DOI:10.1038/217078a0