Serologic Evidence for Human Infection With Adenovirus-Associated Viruses

The adenovirus-associated viruses (AAV) are a newly recognized group of defective viruses that are capable of multiplying only in cell cultures infected with an adenovirus. Their natural history is unknown, since they have been identified only as contaminants of laboratory stocks of adenoviruses. Th...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1968-02, Vol.40 (2), p.319-327
Main Authors: Blacklow, Neil R., Hoggan, M. David, Rowe, Wallace P.
Format: Article
Language:English
Subjects:
Adenoviridae
Adenoviridae Infections - immunology
Adolescent
Adult
Age Factors
Animals
Antibodies
Child
Child, Preschool
Complement Fixation Tests
Culture Techniques
Defective Viruses
Female
Fluorescent Antibody Technique
Haplorhini
Humans
Infant
Male
Neutralization Tests
Satellite Viruses
Virus Replication
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Summary:The adenovirus-associated viruses (AAV) are a newly recognized group of defective viruses that are capable of multiplying only in cell cultures infected with an adenovirus. Their natural history is unknown, since they have been identified only as contaminants of laboratory stocks of adenoviruses. This report describes the detection of antibodies to AAV serotypes 1, 2, and 3 in human sera by neutralization, complement fixation, and immunofluorescence tests. The curve of antibody frequency showed a steep rise between the ages of 1 and 10; about one-half of older children and adults showed antibodies to one or more AAV serotypes. AAV seroconversions were demonstrated by neutralizing and/or CF antibody in 5 of 12 children residing in a receiving home for young children in 1957–58 and in 7 of 28 children residing there in 1965–66. These findings therefore strongly indicate that man is naturally infected with viruses of the AAV group. Captive African green monkeys frequently showed antibody to AAV 4. Antibodies to all 4 AAV serotypes were found in a low proportion of captive but not in wild rhesus monkeys.
ISSN:0027-8874
1460-2105
1460-2105
DOI:10.1093/jnci/40.2.319