Association of coagulation‐related and inflammation‐related genes and factor VIIc levels with stroke: the Cardiovascular Health Study

• Published in: Journal of thrombosis and haemostasis 2011-02, Vol.9 (2), p.267-274
• Main Authors: ZAKAI, N. A., LANGE, L., LONGSTRETH, W. T., O’MEARA, E. S., KELLEY, J. L., FORNAGE, M., NIKERSON, D., CUSHMAN, M., REINER, A. P.
• Format: Article
• Language: English
• Subjects: Blood Coagulation Factors - genetics; cardiovascular disease risk; Cardiovascular Diseases - genetics; Cohort Studies; Factor VII - metabolism; factor VII; Female; genetic epidemiology; hemostasis; Humans; inflammation; Inflammation - genetics; Male; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors; stroke; Stroke - blood; Stroke - genetics
• ISSN: 1538-7933; 1538-7836; 1538-7836
• DOI: 10.1111/j.1538-7836.2010.04149.x

Background: Thrombosis and inflammation are critical in stroke etiology, but associations of coagulation and inflammation gene variants with stroke, and particularly factor VII levels, are inconclusive. Objectives: To test the associations between 736 single‐nucleotide polymorphisms (SNPs) between tagging haplotype patterns of 130 coagulation and inflammation genes, and stroke events, in the 5888 participants aged ≥ 65 years of the observational Cardiovascular Health Study cohort. Patients/Methods: With 16 years of follow‐up, age‐adjusted and sex‐adjusted Cox models were used to estimate associations of SNPs and FVIIc levels with future stroke. Results: Eight hundred and fifteen strokes occurred in 5255 genotyped participants without baseline stroke (748 ischemic strokes; 586 among whites). Among whites, six SNPs were associated with stroke, with a nominal P‐value of