The effect of strontium-substituted hydroxyapatite coating on implant fixation in ovariectomized rats

Abstract This study was designed to investigate the effects of strontium-substituted hydroxyapatite coatings with 10 mol% Ca2+ replaced by Sr2+ (10% SrHA) on implant fixation in ovariectomized (OVX) rats. Coatings of HA and 10%SrHA were prepared on the surface of titanium implant using sol-gel dip m...

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Bibliographic Details
Published in:Biomaterials 2010-12, Vol.31 (34), p.9006-9014
Main Authors: Li, Yunfeng, Li, Qing, Zhu, Songsong, Luo, En, Li, Jihua, Feng, Ge, Liao, Yunmao, Hu, Jing
Format: Article
Language:English
Subjects:
Adhesiveness - drug effects
Advanced Basic Science
Animals
Biomechanical Phenomena - drug effects
Biomedical materials
Bones
Coated Materials, Biocompatible - pharmacology
Coating
Dentistry
Female
Fixation
Hydroxyapatite
Hydroxyapatites - pharmacology
Implants, Experimental
Materials Testing
Microscopy, Atomic Force
Microscopy, Electron, Scanning
Osseointegration
Osteoporosis
Ovariectomy
Photoelectron Spectroscopy
Prosthesis Implantation - methods
Rats
Rats, Sprague-Dawley
Scanning electron microscopy
Strontium
Strontium - pharmacology
Surface coating
Surgical implants
Tibia - diagnostic imaging
Tibia - drug effects
Tibia - pathology
X-Ray Diffraction
X-Ray Microtomography
X-rays
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Summary:Abstract This study was designed to investigate the effects of strontium-substituted hydroxyapatite coatings with 10 mol% Ca2+ replaced by Sr2+ (10% SrHA) on implant fixation in ovariectomized (OVX) rats. Coatings of HA and 10%SrHA were prepared on the surface of titanium implant using sol-gel dip methods, and then characterized by Scanning Electron Microscope, Atomic Force Microscope, X-ray diffraction, X-ray Photoemission Spectroscopy, and an automatic scratch tester. Twelve weeks after bilateral ovariectomy, twenty OVX rats accepted implant insertion in the proximal tibiae, half with HA-coated implants and the other half with 10% SrHA coated implants. After 12-week healing period, 10% SrHA coated implants revealed improved osseointegration compared to HA, with the bone area ratio and bone-to-implant contact increased by 70.9% and 49.9% in histomorphometry, the bone volume ratio and percent osseointegration by 73.7% and 45.2% in micro-CT evaluation, and the maximal push-out force and ultimate shear strength by 107.2% and 132.9% in push out test. These results demonstrated that 10% SrHA coatings could enhance implant osseointegration in OVX rats, and suggested the feasibility of using SrHA coatings to improve implant fixation in osteoporotic bone.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2010.07.112