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Klinefelter's Syndrome, Dizygotic Twinning and Diabetes Mellitus
Engel and Forbes 1,2 noted that chromosomal non-disjunction commonly occurs in families with a genetic predisposition to “autoimmunity”. From a review of the literature, and a study of eighteen patients with chromatin-positive Klinefelter's syndrome, Nielsen 3 proposed that this syndrome is pro...
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| Published in: | Nature (London) 1969-01, Vol.221 (5176), p.175-177 |
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| Language: | English |
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| container_end_page | 177 |
| container_issue | 5176 |
| container_start_page | 175 |
| container_title | Nature (London) |
| container_volume | 221 |
| creator | BURCH, P. R. J. |
| description | Engel and Forbes
1,2
noted that chromosomal non-disjunction commonly occurs in families with a genetic predisposition to “autoimmunity”. From a review of the literature, and a study of eighteen patients with chromatin-positive Klinefelter's syndrome, Nielsen
3
proposed that this syndrome is probably associated with dizygotic twinning. He also summarized the results of three surveys which indicate that the frequency of twin births in sibships containing Turner's syndrome is about twice that in the general population. He concluded
3
that similar mechanisms may be responsible for sex chromosome non-disjunction and dizygotic twinning. |
| doi_str_mv | 10.1038/221175a0 |
| format | article |
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1,2
noted that chromosomal non-disjunction commonly occurs in families with a genetic predisposition to “autoimmunity”. From a review of the literature, and a study of eighteen patients with chromatin-positive Klinefelter's syndrome, Nielsen
3
proposed that this syndrome is probably associated with dizygotic twinning. He also summarized the results of three surveys which indicate that the frequency of twin births in sibships containing Turner's syndrome is about twice that in the general population. He concluded
3
that similar mechanisms may be responsible for sex chromosome non-disjunction and dizygotic twinning.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/221175a0</identifier><identifier>PMID: 5812445</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Autoimmune Diseases ; California ; Denmark ; Diabetes Mellitus - epidemiology ; Diseases in Twins - epidemiology ; England ; Female ; Finland ; Genetics, Population ; Humanities and Social Sciences ; Humans ; Klinefelter Syndrome - epidemiology ; letter ; Male ; Maternal Age ; multidisciplinary ; Pregnancy ; Pregnancy, Multiple ; Probability ; Science ; Science (multidisciplinary) ; Turner Syndrome - immunology ; Wales</subject><ispartof>Nature (London), 1969-01, Vol.221 (5176), p.175-177</ispartof><rights>Springer Nature Limited 1969</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c312t-6f17bb1ad33d61f1150ae56c547db7bdf2fc95a8d28fcc94299f11ba5d96e84c3</citedby><cites>FETCH-LOGICAL-c312t-6f17bb1ad33d61f1150ae56c547db7bdf2fc95a8d28fcc94299f11ba5d96e84c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5812445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BURCH, P. R. J.</creatorcontrib><title>Klinefelter's Syndrome, Dizygotic Twinning and Diabetes Mellitus</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Engel and Forbes
1,2
noted that chromosomal non-disjunction commonly occurs in families with a genetic predisposition to “autoimmunity”. From a review of the literature, and a study of eighteen patients with chromatin-positive Klinefelter's syndrome, Nielsen
3
proposed that this syndrome is probably associated with dizygotic twinning. He also summarized the results of three surveys which indicate that the frequency of twin births in sibships containing Turner's syndrome is about twice that in the general population. He concluded
3
that similar mechanisms may be responsible for sex chromosome non-disjunction and dizygotic twinning.</description><subject>Autoimmune Diseases</subject><subject>California</subject><subject>Denmark</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diseases in Twins - epidemiology</subject><subject>England</subject><subject>Female</subject><subject>Finland</subject><subject>Genetics, Population</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Klinefelter Syndrome - epidemiology</subject><subject>letter</subject><subject>Male</subject><subject>Maternal Age</subject><subject>multidisciplinary</subject><subject>Pregnancy</subject><subject>Pregnancy, Multiple</subject><subject>Probability</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Turner Syndrome - immunology</subject><subject>Wales</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><recordid>eNplkE1LxDAQhoMo67oK_gGhJz_AaiZNmvSmrJ-44sH1XNIkXbK0qSYtsv56I7t68TQw78PLzIPQIeALwJm4JASAM4m30Bgoz1OaC76NxhgTkWKR5btoL4QlxpgBpyM0YgIIpWyMrp4a60xtmt74k5C8rpz2XWvOkxv7tVp0vVXJ_NM6Z90ikU7HtaxMb0LybJrG9kPYRzu1bII52MwJeru7nU8f0tnL_eP0epaqDEif5jXwqgKps0znUAMwLA3LFaNcV7zSNalVwaTQRNRKFZQURYQqyXSRG0FVNkHH6953330MJvRla4OKR0hnuiGUggGBAvMInq5B5bsQvKnLd29b6Vcl4PJHVvkrK6JHm86hao3-Azd2Yn62zkNM3ML4ctkN3sU3_3d9A001cQc</recordid><startdate>19690111</startdate><enddate>19690111</enddate><creator>BURCH, P. R. J.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19690111</creationdate><title>Klinefelter's Syndrome, Dizygotic Twinning and Diabetes Mellitus</title><author>BURCH, P. R. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-6f17bb1ad33d61f1150ae56c547db7bdf2fc95a8d28fcc94299f11ba5d96e84c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Autoimmune Diseases</topic><topic>California</topic><topic>Denmark</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diseases in Twins - epidemiology</topic><topic>England</topic><topic>Female</topic><topic>Finland</topic><topic>Genetics, Population</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Klinefelter Syndrome - epidemiology</topic><topic>letter</topic><topic>Male</topic><topic>Maternal Age</topic><topic>multidisciplinary</topic><topic>Pregnancy</topic><topic>Pregnancy, Multiple</topic><topic>Probability</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Turner Syndrome - immunology</topic><topic>Wales</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BURCH, P. R. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BURCH, P. R. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Klinefelter's Syndrome, Dizygotic Twinning and Diabetes Mellitus</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1969-01-11</date><risdate>1969</risdate><volume>221</volume><issue>5176</issue><spage>175</spage><epage>177</epage><pages>175-177</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Engel and Forbes
1,2
noted that chromosomal non-disjunction commonly occurs in families with a genetic predisposition to “autoimmunity”. From a review of the literature, and a study of eighteen patients with chromatin-positive Klinefelter's syndrome, Nielsen
3
proposed that this syndrome is probably associated with dizygotic twinning. He also summarized the results of three surveys which indicate that the frequency of twin births in sibships containing Turner's syndrome is about twice that in the general population. He concluded
3
that similar mechanisms may be responsible for sex chromosome non-disjunction and dizygotic twinning.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>5812445</pmid><doi>10.1038/221175a0</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1969-01, Vol.221 (5176), p.175-177 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_85121907 |
| source | Springer Nature - Connect here FIRST to enable access |
| subjects | Autoimmune Diseases California Denmark Diabetes Mellitus - epidemiology Diseases in Twins - epidemiology England Female Finland Genetics, Population Humanities and Social Sciences Humans Klinefelter Syndrome - epidemiology letter Male Maternal Age multidisciplinary Pregnancy Pregnancy, Multiple Probability Science Science (multidisciplinary) Turner Syndrome - immunology Wales |
| title | Klinefelter's Syndrome, Dizygotic Twinning and Diabetes Mellitus |
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