Vitamin D Deficiency in Children with Inflammatory Bowel Disease

Background Osteopenia and osteoporosis are commonly seen in inflammatory bowel disease (IBD). Vitamin D deficiency potentially contributes to diminished bone acquisition in childhood. Objectives The objectives of this study were to assess vitamin D in a group of Australian children with IBD and to a...

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Published in:Digestive diseases and sciences 2011-03, Vol.56 (3), p.830-836
Main Authors: Levin, Alon D, Wadhera, Veena, Leach, Steven T, Woodhead, Helen J, Lemberg, Daniel A, Czarina Mendoza-Cruz, A, Day, Andrew S
Format: Article
Language:English
Subjects:
Adolescent
Alfacalcidol
Australia - epidemiology
Biochemistry
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Calcifediol
Child
Children's furniture
Cohort Studies
Corticosteroids
Enteral Nutrition
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal diseases
Hepatology
Humans
Inflammatory bowel disease
Inflammatory Bowel Diseases - blood
Inflammatory Bowel Diseases - complications
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - epidemiology
Male
Medical sciences
Medicine
Medicine & Public Health
Oncology
Original Article
Osteoporosis
Other diseases. Semiology
Pharmacology. Drug treatments
Prevalence
Retrospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Transplant Surgery
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - epidemiology
Vitamin D Deficiency - etiology
Vitamin D Deficiency - prevention & control
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container_title Digestive diseases and sciences
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creator Levin, Alon D
Wadhera, Veena
Leach, Steven T
Woodhead, Helen J
Lemberg, Daniel A
Czarina Mendoza-Cruz, A
Day, Andrew S
description Background Osteopenia and osteoporosis are commonly seen in inflammatory bowel disease (IBD). Vitamin D deficiency potentially contributes to diminished bone acquisition in childhood. Objectives The objectives of this study were to assess vitamin D in a group of Australian children with IBD and to ascertain associations between vitamin D status and key clinical factors, for example disease location and severity. Methods Data were obtained retrospectively from the records of children with IBD who had at least one measurement of serum 25-hydroxyvitamin D (25(OH)D) over a two-year period. Demographic variables, disease activity, inflammatory markers, disease location, duration, and therapy were recorded. Moderate and severe deficiency were defined as 25(OH)D
doi_str_mv 10.1007/s10620-010-1544-3
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Vitamin D deficiency potentially contributes to diminished bone acquisition in childhood. Objectives The objectives of this study were to assess vitamin D in a group of Australian children with IBD and to ascertain associations between vitamin D status and key clinical factors, for example disease location and severity. Methods Data were obtained retrospectively from the records of children with IBD who had at least one measurement of serum 25-hydroxyvitamin D (25(OH)D) over a two-year period. Demographic variables, disease activity, inflammatory markers, disease location, duration, and therapy were recorded. Moderate and severe deficiency were defined as 25(OH)D &lt;51 nmol/l and &lt;30 nmol/l, respectively. Insufficiency was defined as 25(OH)D between 51 and 75 nmol/l. Results Overall, the mean 25(OH)D level in 78 children (104 measurements) was 71.2 (SD ± 26.5) nmol/l. Fifteen (19%) children were vitamin D deficient and 30 (38%) children were insufficient. Levels of 25(OH)D were not associated with disease location or use of immunosuppressive drugs. Children with vitamin D deficiency had greater corticosteroid exposure than those with normal status (P = 0.001). The mean 25(OH)D of 38 children treated with nutritional therapy at diagnosis was higher than for 17 children initially treated with corticosteroids (P = 0.04). Conclusions A high proportion of these Australian children with IBD were vitamin D deficient. This emphasizes the importance of monitoring vitamin D status, and treating deficiency, in the management of pediatric IBD. The possible benefit of nutritional therapy in protection against vitamin D deficiency requires further prospective study.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-010-1544-3</identifier><identifier>PMID: 21222159</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Adolescent ; Alfacalcidol ; Australia - epidemiology ; Biochemistry ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Calcifediol ; Child ; Children's furniture ; Cohort Studies ; Corticosteroids ; Enteral Nutrition ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal diseases ; Hepatology ; Humans ; Inflammatory bowel disease ; Inflammatory Bowel Diseases - blood ; Inflammatory Bowel Diseases - complications ; Inflammatory Bowel Diseases - drug therapy ; Inflammatory Bowel Diseases - epidemiology ; Male ; Medical sciences ; Medicine ; Medicine &amp; Public Health ; Oncology ; Original Article ; Osteoporosis ; Other diseases. Semiology ; Pharmacology. Drug treatments ; Prevalence ; Retrospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Transplant Surgery ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D - analogs &amp; derivatives ; Vitamin D - blood ; Vitamin D deficiency ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - epidemiology ; Vitamin D Deficiency - etiology ; Vitamin D Deficiency - prevention &amp; control</subject><ispartof>Digestive diseases and sciences, 2011-03, Vol.56 (3), p.830-836</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-95ac1ea319a472dd6b39c8457b2af38f083ac1c5c11edca0ae0b54e8eefa193a3</citedby><cites>FETCH-LOGICAL-c524t-95ac1ea319a472dd6b39c8457b2af38f083ac1c5c11edca0ae0b54e8eefa193a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=23972503$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21222159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levin, Alon D</creatorcontrib><creatorcontrib>Wadhera, Veena</creatorcontrib><creatorcontrib>Leach, Steven T</creatorcontrib><creatorcontrib>Woodhead, Helen J</creatorcontrib><creatorcontrib>Lemberg, Daniel A</creatorcontrib><creatorcontrib>Czarina Mendoza-Cruz, A</creatorcontrib><creatorcontrib>Day, Andrew S</creatorcontrib><title>Vitamin D Deficiency in Children with Inflammatory Bowel Disease</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background Osteopenia and osteoporosis are commonly seen in inflammatory bowel disease (IBD). Vitamin D deficiency potentially contributes to diminished bone acquisition in childhood. Objectives The objectives of this study were to assess vitamin D in a group of Australian children with IBD and to ascertain associations between vitamin D status and key clinical factors, for example disease location and severity. Methods Data were obtained retrospectively from the records of children with IBD who had at least one measurement of serum 25-hydroxyvitamin D (25(OH)D) over a two-year period. Demographic variables, disease activity, inflammatory markers, disease location, duration, and therapy were recorded. Moderate and severe deficiency were defined as 25(OH)D &lt;51 nmol/l and &lt;30 nmol/l, respectively. Insufficiency was defined as 25(OH)D between 51 and 75 nmol/l. Results Overall, the mean 25(OH)D level in 78 children (104 measurements) was 71.2 (SD ± 26.5) nmol/l. Fifteen (19%) children were vitamin D deficient and 30 (38%) children were insufficient. Levels of 25(OH)D were not associated with disease location or use of immunosuppressive drugs. Children with vitamin D deficiency had greater corticosteroid exposure than those with normal status (P = 0.001). The mean 25(OH)D of 38 children treated with nutritional therapy at diagnosis was higher than for 17 children initially treated with corticosteroids (P = 0.04). Conclusions A high proportion of these Australian children with IBD were vitamin D deficient. This emphasizes the importance of monitoring vitamin D status, and treating deficiency, in the management of pediatric IBD. The possible benefit of nutritional therapy in protection against vitamin D deficiency requires further prospective study.</description><subject>Adolescent</subject><subject>Alfacalcidol</subject><subject>Australia - epidemiology</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Calcifediol</subject><subject>Child</subject><subject>Children's furniture</subject><subject>Cohort Studies</subject><subject>Corticosteroids</subject><subject>Enteral Nutrition</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal diseases</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory Bowel Diseases - blood</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Inflammatory Bowel Diseases - drug therapy</subject><subject>Inflammatory Bowel Diseases - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Osteoporosis</subject><subject>Other diseases. Semiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Antiinflammatory agents</topic><topic>Calcifediol</topic><topic>Child</topic><topic>Children's furniture</topic><topic>Cohort Studies</topic><topic>Corticosteroids</topic><topic>Enteral Nutrition</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastrointestinal diseases</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory Bowel Diseases - blood</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Inflammatory Bowel Diseases - drug therapy</topic><topic>Inflammatory Bowel Diseases - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Osteoporosis</topic><topic>Other diseases. Semiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Transplant Surgery</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs &amp; derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D deficiency</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin D Deficiency - etiology</topic><topic>Vitamin D Deficiency - prevention &amp; control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levin, Alon D</creatorcontrib><creatorcontrib>Wadhera, Veena</creatorcontrib><creatorcontrib>Leach, Steven T</creatorcontrib><creatorcontrib>Woodhead, Helen J</creatorcontrib><creatorcontrib>Lemberg, Daniel A</creatorcontrib><creatorcontrib>Czarina Mendoza-Cruz, A</creatorcontrib><creatorcontrib>Day, Andrew S</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Family Health</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levin, Alon D</au><au>Wadhera, Veena</au><au>Leach, Steven T</au><au>Woodhead, Helen J</au><au>Lemberg, Daniel A</au><au>Czarina Mendoza-Cruz, A</au><au>Day, Andrew S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D Deficiency in Children with Inflammatory Bowel Disease</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>56</volume><issue>3</issue><spage>830</spage><epage>836</epage><pages>830-836</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Background Osteopenia and osteoporosis are commonly seen in inflammatory bowel disease (IBD). Vitamin D deficiency potentially contributes to diminished bone acquisition in childhood. Objectives The objectives of this study were to assess vitamin D in a group of Australian children with IBD and to ascertain associations between vitamin D status and key clinical factors, for example disease location and severity. Methods Data were obtained retrospectively from the records of children with IBD who had at least one measurement of serum 25-hydroxyvitamin D (25(OH)D) over a two-year period. Demographic variables, disease activity, inflammatory markers, disease location, duration, and therapy were recorded. Moderate and severe deficiency were defined as 25(OH)D &lt;51 nmol/l and &lt;30 nmol/l, respectively. Insufficiency was defined as 25(OH)D between 51 and 75 nmol/l. Results Overall, the mean 25(OH)D level in 78 children (104 measurements) was 71.2 (SD ± 26.5) nmol/l. Fifteen (19%) children were vitamin D deficient and 30 (38%) children were insufficient. Levels of 25(OH)D were not associated with disease location or use of immunosuppressive drugs. Children with vitamin D deficiency had greater corticosteroid exposure than those with normal status (P = 0.001). The mean 25(OH)D of 38 children treated with nutritional therapy at diagnosis was higher than for 17 children initially treated with corticosteroids (P = 0.04). Conclusions A high proportion of these Australian children with IBD were vitamin D deficient. This emphasizes the importance of monitoring vitamin D status, and treating deficiency, in the management of pediatric IBD. The possible benefit of nutritional therapy in protection against vitamin D deficiency requires further prospective study.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>21222159</pmid><doi>10.1007/s10620-010-1544-3</doi><tpages>7</tpages></addata></record>
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source Springer Nature
subjects Adolescent
Alfacalcidol
Australia - epidemiology
Biochemistry
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Calcifediol
Child
Children's furniture
Cohort Studies
Corticosteroids
Enteral Nutrition
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal diseases
Hepatology
Humans
Inflammatory bowel disease
Inflammatory Bowel Diseases - blood
Inflammatory Bowel Diseases - complications
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - epidemiology
Male
Medical sciences
Medicine
Medicine & Public Health
Oncology
Original Article
Osteoporosis
Other diseases. Semiology
Pharmacology. Drug treatments
Prevalence
Retrospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Transplant Surgery
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - epidemiology
Vitamin D Deficiency - etiology
Vitamin D Deficiency - prevention & control
title Vitamin D Deficiency in Children with Inflammatory Bowel Disease
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