Patterns of language decline in non-fluent primary progressive aphasia

Language samples collected yearly for up to 11 years post-onset of symptoms from four subjects presenting with non-fluent primary progressive aphasia (PPA) were analyzed and compared with samples collected from both non-brain-damaged subjects and those with agrammatic Broca's aphasia resulting...

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Bibliographic Details
Published in:Aphasiology 1997-04, Vol.11 (4-5), p.297-321
Main Authors: Thompson, C. K., Ballard, K. J., Tait, M. E., Weintraub, S., Mesulam, M.
Format: Article
Language:English
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Summary:Language samples collected yearly for up to 11 years post-onset of symptoms from four subjects presenting with non-fluent primary progressive aphasia (PPA) were analyzed and compared with samples collected from both non-brain-damaged subjects and those with agrammatic Broca's aphasia resulting from a single left-hemisphere stroke. Extensive analysis of lexical and morphosyntactic variables in these samples revealed two patterns of expressive language decline in the PPA subjects-one resembling that seen in our agrammatic aphasic subjects-i.e. impaired production of closed-class elements and loss of sentential structures governed by these elements-and the other characterized by advancing word-retrieval difficulties. These data are relevant for patient-management purposes and, in addition, they provide information relevant to language representation and organization.
ISSN:0268-7038
1464-5041
DOI:10.1080/02687039708248473