Tuberculosis in Liver Transplant Recipients: Prophylaxis in an Endemic Area

• Published in: Transplantation proceedings 2011, Vol.43 (1), p.199-202
• Main Authors: Agoglia, L, Balbi, E, Halpern, M, Roma, J, Carius, L, Martinho, J.M, Moreira, L.P
• Format: Article
• Language: English
• Subjects: Adult; Antitubercular Agents - therapeutic use; Bacterial diseases; Biological and medical sciences; Brazil - epidemiology; Endemic Diseases; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Human bacterial diseases; Humans; Infectious diseases; Liver Transplantation; Male; Medical sciences; Retrospective Studies; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Tuberculosis - drug therapy; Tuberculosis - epidemiology; Tuberculosis - prevention & control; Tuberculosis and atypical mycobacterial infections
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2010.12.033

Abstract Background Tuberculosis (TB) has a high prevalence in Brazil. The scenario of liver transplantation (LT) creates challenges: atypical presentation, treatment hepatotoxicity, and increased mortality. The majority of TB cases after transplantation represent reactivation of latent infections; therefore, prophylaxis (PX) plays a major role. The aim of this study was to evaluate the benefits of PX after LT based on a pretransplantation tuberculin test (TT) in an endemic area. Methods Retrospective analysis of medical data from 376 adult cirrhotic patients undergoing OLT from 2001 to 2009. Results Among 191 selected patients, 137 (71%) showed a pretransplant TT including 41 (30%) with a TT ≥5 mm. The 17 (40%) of these patients who were prescribed PX did not experience TB. Prophylaxis was discontinued in 5 patients (20%) owing to suspicion of hepatotoxicity (medium serum alanine transaminase 175 U/L). In the group without PX, we diagnosed 1 case of pulmonary TB. The overall prevalence of anergic patients in the cirrhotic phase was 65% and prevalence of TB 1%. Conclusions The prevalence of TB was similar to that reported in the literature, but positivity to TT was higher (34% vs 25%), possibly because of the endemicity of the area. There was a lower prevalence of extrapulmonary disease and no mortality. No patient undergoing PX with isoniazid, although incomplete due to suspicion of hepatotoxicity displayed TB. One patient without PX was affected by TB. The drug was effective but not always safe.