Inhibitory effects of fruit extracts on nitric oxide-induced proliferation in MCF-7 cells

► We analysed the effects of 13 tropical fruits on nitric oxide. ► Nitric oxide inhibitors are known to decrease tumour growth. ► The fruits inhibited nitric oxide-induced proliferation of MCF-7. ► The fruits also had high polyphenol and flavonoid content. ► Phytochemicals in fruits scavenge nitric...

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Bibliographic Details
Published in:Food chemistry 2011-06, Vol.126 (3), p.956-960
Main Authors: Jayakumar, Rajarajeswaran, Kanthimathi, M.S.
Format: Article
Language:English
Subjects:
anticarcinogenic activity
apples
Biological and medical sciences
Breast
breast neoplasms
Cancer
cell proliferation
chiku
dragon fruit
durians
Flavonoids
Food industries
Free radicals
Fruit and vegetable industries
fruit extracts
Fruits
Fundamental and applied biological sciences. Psychology
grapes
human cell lines
human diseases
Hylocereus
Inhibitors
litchis
Manilkara zapota
Nitric oxide
phytochemicals
Polyphenols
Pomegranates
Scavenging of nitric oxide
Sodium nitroprusside
Therapy
tropical and subtropical fruits
Tumours
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Summary:► We analysed the effects of 13 tropical fruits on nitric oxide. ► Nitric oxide inhibitors are known to decrease tumour growth. ► The fruits inhibited nitric oxide-induced proliferation of MCF-7. ► The fruits also had high polyphenol and flavonoid content. ► Phytochemicals in fruits scavenge nitric oxide and inhibit MCF-7 cell proliferation. Nitric oxide is a free radical involved in the pathogenesis of cancer by increasing tumour vascularization and metastasis. Studies using nitric oxide inhibitors have shown decrease in tumour growth and a role in cancer therapy. To analyse the effect of fruits on nitric oxide, we carried out experiments using a nitric oxide donor on the breast cancer cell line, MCF-7. Proliferating MCF-7 cells were treated with the methanolic extract of the fruits. The inhibitory activity of fruit extracts on cell proliferation was measured using the MTT assay. Chiku and dragon fruit showed high inhibitory activity when compared to the other fruits tested. The total polyphenol and flavonoid content and nitric oxide scavenging activity were found to be high in pomegranate, chiku, litchi, durian, grape and apple. This study shows that phytochemicals present in fruits scavenge nitric oxide and inhibit MCF-7 cell proliferation.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2010.11.093