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Variability in subcortical aphasia is due to variable sites of cortical hypoperfusion
A variety of fluent and nonfluent aphasias have been reported after left basal ganglia stroke. It has been speculated that this heterogeneity may reflect variations in cortical hypoperfusion resulting from large vessel stenosis. To test this hypothesis, a consecutive series of 24 patients with left...
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| Published in: | Brain and language 2004-06, Vol.89 (3), p.524-530 |
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| Main Authors: | , , , , , , |
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| container_end_page | 530 |
| container_issue | 3 |
| container_start_page | 524 |
| container_title | Brain and language |
| container_volume | 89 |
| creator | Hillis, Argye E. Barker, Peter B. Wityk, Robert J. Aldrich, Eric M. Restrepo, Lucas Breese, Elisabeth L. Work, Melissa |
| description | A variety of fluent and nonfluent aphasias have been reported after left basal ganglia stroke. It has been speculated that this heterogeneity may reflect variations in cortical hypoperfusion resulting from large vessel stenosis. To test this hypothesis, a consecutive series of 24 patients with left caudate infarct identified with diffusion-weighted imaging underwent language testing and perfusion-weighted imaging |
| doi_str_mv | 10.1016/j.bandl.2004.01.007 |
| format | article |
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h from onset of symptoms. Specific regions in perisylvian cortex were rated for the percentage of the region that was hypoperfused. Aphasia type was determined on the basis of speech fluency, comprehension, and repetition performance on the language tests. Association between aphasia type/language impairment and regions of hypoperfusion were identified with Fisher’s exact tests. Results demonstrated that in patients with acute left caudate infarct, the presence and type of aphasia reflected regions of hypoperfusion, and generally followed predictions based on chronic lesion studies, regarding anatomical lesions associated with classic aphasia types.</description><identifier>ISSN: 0093-934X</identifier><identifier>EISSN: 1090-2155</identifier><identifier>DOI: 10.1016/j.bandl.2004.01.007</identifier><identifier>PMID: 15120543</identifier><identifier>CODEN: BRLGAZ</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Aphasia ; Aphasia - classification ; Aphasia - etiology ; Aphasia - pathology ; Basal Ganglia Cerebrovascular Disease - complications ; Basal Ganglia Cerebrovascular Disease - pathology ; Basal ganglia stroke ; Biological and medical sciences ; Cerebral Infarction - complications ; Cerebral Infarction - pathology ; Cerebrovascular disease/stroke ; Etiology ; Female ; Humans ; Hypothesis Testing ; Language Fluency ; Language Tests ; Magnetic Resonance Imaging ; Male ; Measures (Individuals) ; Medical sciences ; Middle Aged ; Neurological Impairments ; Organic mental disorders. Neuropsychology ; Patients ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Regional Blood Flow ; Subcortical aphasia</subject><ispartof>Brain and language, 2004-06, Vol.89 (3), p.524-530</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-aa87510c66c92b77a231fe33b68391fec4b4ab57f31dec1ed6f159bf2267de23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902,31247</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ730889$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15748106$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15120543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hillis, Argye E.</creatorcontrib><creatorcontrib>Barker, Peter B.</creatorcontrib><creatorcontrib>Wityk, Robert J.</creatorcontrib><creatorcontrib>Aldrich, Eric M.</creatorcontrib><creatorcontrib>Restrepo, Lucas</creatorcontrib><creatorcontrib>Breese, Elisabeth L.</creatorcontrib><creatorcontrib>Work, Melissa</creatorcontrib><title>Variability in subcortical aphasia is due to variable sites of cortical hypoperfusion</title><title>Brain and language</title><addtitle>Brain Lang</addtitle><description>A variety of fluent and nonfluent aphasias have been reported after left basal ganglia stroke. It has been speculated that this heterogeneity may reflect variations in cortical hypoperfusion resulting from large vessel stenosis. To test this hypothesis, a consecutive series of 24 patients with left caudate infarct identified with diffusion-weighted imaging underwent language testing and perfusion-weighted imaging <24
h from onset of symptoms. Specific regions in perisylvian cortex were rated for the percentage of the region that was hypoperfused. Aphasia type was determined on the basis of speech fluency, comprehension, and repetition performance on the language tests. Association between aphasia type/language impairment and regions of hypoperfusion were identified with Fisher’s exact tests. Results demonstrated that in patients with acute left caudate infarct, the presence and type of aphasia reflected regions of hypoperfusion, and generally followed predictions based on chronic lesion studies, regarding anatomical lesions associated with classic aphasia types.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aphasia</subject><subject>Aphasia - classification</subject><subject>Aphasia - etiology</subject><subject>Aphasia - pathology</subject><subject>Basal Ganglia Cerebrovascular Disease - complications</subject><subject>Basal Ganglia Cerebrovascular Disease - pathology</subject><subject>Basal ganglia stroke</subject><subject>Biological and medical sciences</subject><subject>Cerebral Infarction - complications</subject><subject>Cerebral Infarction - pathology</subject><subject>Cerebrovascular disease/stroke</subject><subject>Etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothesis Testing</subject><subject>Language Fluency</subject><subject>Language Tests</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Measures (Individuals)</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurological Impairments</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Patients</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Regional Blood Flow</subject><subject>Subcortical aphasia</subject><issn>0093-934X</issn><issn>1090-2155</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>7SW</sourceid><sourceid>7T9</sourceid><recordid>eNqFkU1v1DAQhi0EokvhF4CQL3BLmIntODlwQFX5UiUuBXGzHGesepVNgp1U2n-P240KJzjNSO8zo9EzjL1EKBGwfrcvOzv2Q1kByBKwBNCP2A6hhaJCpR6zHUArilbIn2fsWUp7AETZ4FN2hgorUFLs2PcfNgbbhSEsRx5GntbOTXEJzg7czjc2BctD4v1KfJn47T08EE9hocQnzx_gm-M8zRT9msI0PmdPvB0SvdjqObv-eHl98bm4-vbpy8WHq8IpEEthbaMVgqtr11ad1rYS6EmIrm5EmzsnO2k7pb3AnhxSX3tUbeerqtY9VeKcvT2tneP0a6W0mENIjobBjjStyTRKtShr8V9QY9NqCTKD4gS6OKUUyZs5hoONR4Ng7qybvbm3bu6sG0CTreep19v6tTtQ_2dm05yBNxtgU5blox1dSH9xOv8F6sy9OnEUg3uIL79qAU3T5vj9Fment4GiSS7Q6KgPkdxi-in8887fLBuq-w</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Hillis, Argye E.</creator><creator>Barker, Peter B.</creator><creator>Wityk, Robert J.</creator><creator>Aldrich, Eric M.</creator><creator>Restrepo, Lucas</creator><creator>Breese, Elisabeth L.</creator><creator>Work, Melissa</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope><scope>7T9</scope></search><sort><creationdate>20040601</creationdate><title>Variability in subcortical aphasia is due to variable sites of cortical hypoperfusion</title><author>Hillis, Argye E. ; Barker, Peter B. ; Wityk, Robert J. ; Aldrich, Eric M. ; Restrepo, Lucas ; Breese, Elisabeth L. ; Work, Melissa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-aa87510c66c92b77a231fe33b68391fec4b4ab57f31dec1ed6f159bf2267de23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aphasia</topic><topic>Aphasia - classification</topic><topic>Aphasia - etiology</topic><topic>Aphasia - pathology</topic><topic>Basal Ganglia Cerebrovascular Disease - complications</topic><topic>Basal Ganglia Cerebrovascular Disease - pathology</topic><topic>Basal ganglia stroke</topic><topic>Biological and medical sciences</topic><topic>Cerebral Infarction - complications</topic><topic>Cerebral Infarction - pathology</topic><topic>Cerebrovascular disease/stroke</topic><topic>Etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothesis Testing</topic><topic>Language Fluency</topic><topic>Language Tests</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Measures (Individuals)</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurological Impairments</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Patients</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Regional Blood Flow</topic><topic>Subcortical aphasia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hillis, Argye E.</creatorcontrib><creatorcontrib>Barker, Peter B.</creatorcontrib><creatorcontrib>Wityk, Robert J.</creatorcontrib><creatorcontrib>Aldrich, Eric M.</creatorcontrib><creatorcontrib>Restrepo, Lucas</creatorcontrib><creatorcontrib>Breese, Elisabeth L.</creatorcontrib><creatorcontrib>Work, Melissa</creatorcontrib><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><collection>Linguistics and Language Behavior Abstracts (LLBA)</collection><jtitle>Brain and language</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hillis, Argye E.</au><au>Barker, Peter B.</au><au>Wityk, Robert J.</au><au>Aldrich, Eric M.</au><au>Restrepo, Lucas</au><au>Breese, Elisabeth L.</au><au>Work, Melissa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ730889</ericid><atitle>Variability in subcortical aphasia is due to variable sites of cortical hypoperfusion</atitle><jtitle>Brain and language</jtitle><addtitle>Brain Lang</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>89</volume><issue>3</issue><spage>524</spage><epage>530</epage><pages>524-530</pages><issn>0093-934X</issn><eissn>1090-2155</eissn><coden>BRLGAZ</coden><abstract>A variety of fluent and nonfluent aphasias have been reported after left basal ganglia stroke. It has been speculated that this heterogeneity may reflect variations in cortical hypoperfusion resulting from large vessel stenosis. To test this hypothesis, a consecutive series of 24 patients with left caudate infarct identified with diffusion-weighted imaging underwent language testing and perfusion-weighted imaging <24
h from onset of symptoms. Specific regions in perisylvian cortex were rated for the percentage of the region that was hypoperfused. Aphasia type was determined on the basis of speech fluency, comprehension, and repetition performance on the language tests. Association between aphasia type/language impairment and regions of hypoperfusion were identified with Fisher’s exact tests. Results demonstrated that in patients with acute left caudate infarct, the presence and type of aphasia reflected regions of hypoperfusion, and generally followed predictions based on chronic lesion studies, regarding anatomical lesions associated with classic aphasia types.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>15120543</pmid><doi>10.1016/j.bandl.2004.01.007</doi><tpages>7</tpages></addata></record> |
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| ispartof | Brain and language, 2004-06, Vol.89 (3), p.524-530 |
| issn | 0093-934X 1090-2155 |
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| source | ScienceDirect Freedom Collection; ERIC; Linguistics and Language Behavior Abstracts (LLBA) |
| subjects | Adult Adult and adolescent clinical studies Aged Aged, 80 and over Aphasia Aphasia - classification Aphasia - etiology Aphasia - pathology Basal Ganglia Cerebrovascular Disease - complications Basal Ganglia Cerebrovascular Disease - pathology Basal ganglia stroke Biological and medical sciences Cerebral Infarction - complications Cerebral Infarction - pathology Cerebrovascular disease/stroke Etiology Female Humans Hypothesis Testing Language Fluency Language Tests Magnetic Resonance Imaging Male Measures (Individuals) Medical sciences Middle Aged Neurological Impairments Organic mental disorders. Neuropsychology Patients Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Regional Blood Flow Subcortical aphasia |
| title | Variability in subcortical aphasia is due to variable sites of cortical hypoperfusion |
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