Effect of sodium selenosulfate on restoring activities of selenium-dependent enzymes and selenium retention compared with sodium selenite in vitro and in vivo

Sodium selenosulfate has been extensively used as a precursor of selenide ions in the preparation of nano Se-containing compounds. Its biological properties remain completely unknown. Sodium selenosulfate and sodium selenite were added to the medium of HepG2 cells and administered intraperitoneally...

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Bibliographic Details
Published in:Biological trace element research 2007-06, Vol.117 (1-3), p.77-88
Main Authors: Peng, Dungeng, Zhang, Jinsong, Liu, Qinliang
Format: Article
Language:English
Subjects:
Animals
Biological properties
Body weight
Cell Line, Tumor
Glutathione Peroxidase - metabolism
Humans
Kidneys
Liver
Male
Mice
Retention
Rodents
Selenium
Selenium - chemistry
Selenium - deficiency
Selenium - physiology
Selenium Compounds - pharmacology
Sodium
Sodium Selenite - pharmacology
Sulfates - pharmacology
Thioredoxin-Disulfide Reductase - metabolism
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Summary:Sodium selenosulfate has been extensively used as a precursor of selenide ions in the preparation of nano Se-containing compounds. Its biological properties remain completely unknown. Sodium selenosulfate and sodium selenite were added to the medium of HepG2 cells and administered intraperitoneally at a dose of 0.1 mg Se/kg body weight to selenium-deficient mice, respectively. Both of the selenium compounds could increase the activities of glutathione peroxidase (GPx) and thioredoxin reductase (TrxR) in a dose-dependent manner in cells and efficiently restore selenium retention and activities of GPx and TrxR in mice. All of the variables were in correlation with the Se supply. There was no distinction in elevating activities of GPx and TrxR between selenosulfate and selenite in vitro. After a 2-d supply of selenosulfate, the activity of GPx in the liver was 65% (p
ISSN:0163-4984
1559-0720
DOI:10.1007/BF02698085