Lewis Acid-Mediated Michaelis−Arbuzov Reaction at Room Temperature: A Facile Preparation of Arylmethyl/Heteroarylmethyl Phosphonates

A facile preparation of arylmethyl and heteroarylmethyl phosphonate esters was achieved involving a Lewis acid mediated Michaelis−Arbuzov reaction at room temperature. Interaction of arylmethyl halides/alcohols with triethyl phosphite in the presence of Lewis acid at room temperature afforded phosph...

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Bibliographic Details
Published in:Organic letters 2011-03, Vol.13 (6), p.1270-1273
Main Authors: Rajeshwaran, Ganesan Gobi, Nandakumar, Meganathan, Sureshbabu, Radhakrishnan, Mohanakrishnan, Arasambattu K
Format: Article
Language:English
Subjects:
Esters
Lewis Acids - chemistry
Molecular Structure
Organophosphonates - chemical synthesis
Organophosphonates - chemistry
Temperature
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Summary:A facile preparation of arylmethyl and heteroarylmethyl phosphonate esters was achieved involving a Lewis acid mediated Michaelis−Arbuzov reaction at room temperature. Interaction of arylmethyl halides/alcohols with triethyl phosphite in the presence of Lewis acid at room temperature afforded phosphonate esters in good yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol1029436