An antimicrobial protein, lactoferrin exists in the sweat: proteomic analysis of sweat

:  The main function of the eccrine gland has been considered to be thermoregulation. Recently, it has been reported that antimicrobial peptides including cathelicidin and dermcidin exist in the sweat. Lactoferrin is found in body fluids such as milk tears and saliva. It is known as a component of h...

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Bibliographic Details
Published in:Experimental dermatology 2011-04, Vol.20 (4), p.369-371
Main Authors: Park, Ji-Hye, Park, Geon-Tae, Cho, Ick Hyun, Sim, Seon-Mi, Yang, Jun-Mo, Lee, Dong-Youn
Format: Article
Language:English
Subjects:
Anti-Infective Agents - analysis
Antimicrobial agents
antimicrobial peptide
Antimicrobial peptides
Biological and medical sciences
Body fluids
cathelicidins
Dermatology
eccrine gland
Eccrine Glands - chemistry
Eccrine Glands - secretion
Enzyme-linked immunosorbent assay
Glands
Humans
Immunohistochemistry
Infection
Inflammation
lactoferrin
Lactoferrin - analysis
Medical sciences
Milk
Proteomics
Saliva
Skin
Sweat
Sweat - chemistry
Tears
Thermoregulation
Western blotting
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Summary::  The main function of the eccrine gland has been considered to be thermoregulation. Recently, it has been reported that antimicrobial peptides including cathelicidin and dermcidin exist in the sweat. Lactoferrin is found in body fluids such as milk tears and saliva. It is known as a component of host defense against infection and inflammation. In this study, we explored whether lactoferrin is produced by eccrine glands, thereby establishing its potential role in the skin defense. By immunohistochemistry, lactoferrin was detected in eccrine glands of normal human skin. In Western blot analysis, lactoferrin was found in sweat and skin surface substances obtained from healthy volunteers. By proteomic analysis, lactoferrin and other antimicrobial peptides were detected in sweat. In addition, we measured the concentration of lactoferrin in sweat by enzyme‐linked immunosorbent assay. These findings suggest that lactoferrin may contribute to skin defense against infection through its secretion in sweat.
ISSN:0906-6705
1600-0625
DOI:10.1111/j.1600-0625.2010.01218.x