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Oral iron supplementation leads to oxidative imbalance in anemic women: A prospective study
Summary Background & aims This study was aimed to assess the desirable and undesirable effects of iron (100 mg/day as ferrous sulphate) and folic acid (500 μg/day) supplementation in iron deficient anemic women. Methods Iron and folic acid supplementations were given to 117 anemic women (mild = ...
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| Published in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2011-04, Vol.30 (2), p.188-193 |
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| container_end_page | 193 |
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| container_title | Clinical nutrition (Edinburgh, Scotland) |
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| creator | Mani Tiwari, Amit Kumar Mahdi, Abbas Ali Chandyan, Sudarshna Zahra, Fatima Godbole, Madan Mohan Jaiswar, Shyam Pyari Srivastava, Vinod Kumar Singh Negi, Mahendra Pal |
| description | Summary Background & aims This study was aimed to assess the desirable and undesirable effects of iron (100 mg/day as ferrous sulphate) and folic acid (500 μg/day) supplementation in iron deficient anemic women. Methods Iron and folic acid supplementations were given to 117 anemic women (mild = 55, moderate = 40, and severe = 22) and 60 age matched placebo treated (100 mg cane sugar) non-anemic controls for 100 days. Blood index values, oxidative stress parameters, antioxidant enzymes and vitamins were estimated as per standard protocols. Results Haemoglobin (Hb) levels along with antioxidant enzymes, namely catalase, superoxide dismutase (SOD), glutathione reductase (GSH-Rd), reduced glutathione (GSH) and total antioxidant capacity (TAC) were found significantly increased ( P |
| doi_str_mv | 10.1016/j.clnu.2010.08.001 |
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Methods Iron and folic acid supplementations were given to 117 anemic women (mild = 55, moderate = 40, and severe = 22) and 60 age matched placebo treated (100 mg cane sugar) non-anemic controls for 100 days. Blood index values, oxidative stress parameters, antioxidant enzymes and vitamins were estimated as per standard protocols. Results Haemoglobin (Hb) levels along with antioxidant enzymes, namely catalase, superoxide dismutase (SOD), glutathione reductase (GSH-Rd), reduced glutathione (GSH) and total antioxidant capacity (TAC) were found significantly increased ( P < 0.01) in anemic women after treatment. However, the glutathione peroxidase (GSH-Px) and antioxidant vitamins A, C and E were found significantly decreased ( P < 0.01) in all treated groups. Lipid peroxide levels (LPO), protein carbonyl (PC), conjugated dienes (CD), lipid hydroperoxide (LOOH) and oxidized glutathione (GSSG) levels were found significantly increased ( P < 0.01) after oral iron supplementation groups. Moreover, undesirable side effects of iron supplementation were observed maximally in mild as compared with moderate and severe anemic groups, whereas nausea, vomiting, systemic reactions were negligible in all treated subjects. Conclusion Study found recommended dose of iron effective for improving Hb, but at the cost of increased oxidative stress (mild > moderate > severe). It is suggested that blind iron supplementation should be avoided and shall be provided on need basis.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2010.08.001</identifier><identifier>PMID: 20888091</identifier><identifier>CODEN: CLNUDP</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Administration, Oral ; Adult ; adverse effects ; Analysis of Variance ; Anemia ; Anemia, Iron-Deficiency - therapy ; Anemias. Hemoglobinopathies ; Antioxidant ; antioxidant activity ; antioxidants ; Antioxidants - analysis ; Biological and medical sciences ; blood ; cane sugar ; Dietary Supplements ; Diseases of red blood cells ; Feeding. Feeding behavior ; Female ; ferrous sulfate ; folic acid ; Folic Acid - administration & dosage ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; glutathione ; Glutathione - blood ; glutathione peroxidase ; glutathione-disulfide reductase ; Hematinics - administration & dosage ; Hematologic and hematopoietic diseases ; hemoglobin ; Humans ; iron ; Iron deficiency ; Iron supplementation ; Iron, Dietary - administration & dosage ; lipids ; Medical sciences ; Nutritional deficiency ; Oxidant ; Oxidative Stress ; peroxides ; Prospective Studies ; superoxide dismutase ; Superoxide Dismutase - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; vitamin A ; women ; Young Adult</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2011-04, Vol.30 (2), p.188-193</ispartof><rights>Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-5f7fa8ebff8a318a7fea883c463e27dfd6ba8047c6c36b41bbe7b6a22dbc8d9e3</citedby><cites>FETCH-LOGICAL-c464t-5f7fa8ebff8a318a7fea883c463e27dfd6ba8047c6c36b41bbe7b6a22dbc8d9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24045455$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20888091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mani Tiwari, Amit Kumar</creatorcontrib><creatorcontrib>Mahdi, Abbas Ali</creatorcontrib><creatorcontrib>Chandyan, Sudarshna</creatorcontrib><creatorcontrib>Zahra, Fatima</creatorcontrib><creatorcontrib>Godbole, Madan Mohan</creatorcontrib><creatorcontrib>Jaiswar, Shyam Pyari</creatorcontrib><creatorcontrib>Srivastava, Vinod Kumar</creatorcontrib><creatorcontrib>Singh Negi, Mahendra Pal</creatorcontrib><title>Oral iron supplementation leads to oxidative imbalance in anemic women: A prospective study</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Summary Background & aims This study was aimed to assess the desirable and undesirable effects of iron (100 mg/day as ferrous sulphate) and folic acid (500 μg/day) supplementation in iron deficient anemic women. Methods Iron and folic acid supplementations were given to 117 anemic women (mild = 55, moderate = 40, and severe = 22) and 60 age matched placebo treated (100 mg cane sugar) non-anemic controls for 100 days. Blood index values, oxidative stress parameters, antioxidant enzymes and vitamins were estimated as per standard protocols. Results Haemoglobin (Hb) levels along with antioxidant enzymes, namely catalase, superoxide dismutase (SOD), glutathione reductase (GSH-Rd), reduced glutathione (GSH) and total antioxidant capacity (TAC) were found significantly increased ( P < 0.01) in anemic women after treatment. However, the glutathione peroxidase (GSH-Px) and antioxidant vitamins A, C and E were found significantly decreased ( P < 0.01) in all treated groups. Lipid peroxide levels (LPO), protein carbonyl (PC), conjugated dienes (CD), lipid hydroperoxide (LOOH) and oxidized glutathione (GSSG) levels were found significantly increased ( P < 0.01) after oral iron supplementation groups. Moreover, undesirable side effects of iron supplementation were observed maximally in mild as compared with moderate and severe anemic groups, whereas nausea, vomiting, systemic reactions were negligible in all treated subjects. Conclusion Study found recommended dose of iron effective for improving Hb, but at the cost of increased oxidative stress (mild > moderate > severe). It is suggested that blind iron supplementation should be avoided and shall be provided on need basis.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>adverse effects</subject><subject>Analysis of Variance</subject><subject>Anemia</subject><subject>Anemia, Iron-Deficiency - therapy</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Antioxidant</subject><subject>antioxidant activity</subject><subject>antioxidants</subject><subject>Antioxidants - analysis</subject><subject>Biological and medical sciences</subject><subject>blood</subject><subject>cane sugar</subject><subject>Dietary Supplements</subject><subject>Diseases of red blood cells</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>ferrous sulfate</subject><subject>folic acid</subject><subject>Folic Acid - administration & dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>glutathione</subject><subject>Glutathione - blood</subject><subject>glutathione peroxidase</subject><subject>glutathione-disulfide reductase</subject><subject>Hematinics - administration & dosage</subject><subject>Hematologic and hematopoietic diseases</subject><subject>hemoglobin</subject><subject>Humans</subject><subject>iron</subject><subject>Iron deficiency</subject><subject>Iron supplementation</subject><subject>Iron, Dietary - administration & dosage</subject><subject>lipids</subject><subject>Medical sciences</subject><subject>Nutritional deficiency</subject><subject>Oxidant</subject><subject>Oxidative Stress</subject><subject>peroxides</subject><subject>Prospective Studies</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>vitamin A</subject><subject>women</subject><subject>Young Adult</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kktv1DAURi0EotPCH2AB3qCuMviROA6qkKqKl1Spi9IVC8uxr5GHvLCTwvx7bpgBJBas4tjnXn86voQ842zLGVevdlvXDctWMNxgessYf0A2vJKi4I2WD8mGCcWLSvHyhJzmvGOMVbLWj8mJYFpr1vAN-XyTbEdjGgeal2nqoIdhtnPE_w6sz3Qe6fgjety6Bxr71nZ2cLgaqB2gj45-H7HkNb2kUxrzBO4XmOfF75-QR8F2GZ4ev2fk7t3bT1cfiuub9x-vLq8LV6pyLqpQB6uhDUFbybWtA1itJR5KELUPXrVWs7J2yknVlrxtoW6VFcK3TvsG5Bk5P_TFBN8WyLPpY3bQYVIYl2x01YiGMSmQFAfSYdacIJgpxd6mveHMrE7NzqxOzerUMG3QKRY9P7Zf2h78n5LfEhF4eQRsdrYLCQ3F_JcrWVmVVYXciwMX7Gjsl4TM3S3eVOItiiu5dro4EIC67iMkk10E9O1jQrPGj_H_Sd_8U-66OETM9BX2kHfjkgZ8CMNNFoaZ23U-1vHgOBk4N0r-BO_ztMI</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Mani Tiwari, Amit Kumar</creator><creator>Mahdi, Abbas Ali</creator><creator>Chandyan, Sudarshna</creator><creator>Zahra, Fatima</creator><creator>Godbole, Madan Mohan</creator><creator>Jaiswar, Shyam Pyari</creator><creator>Srivastava, Vinod Kumar</creator><creator>Singh Negi, Mahendra Pal</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Oral iron supplementation leads to oxidative imbalance in anemic women: A prospective study</title><author>Mani Tiwari, Amit Kumar ; Mahdi, Abbas Ali ; Chandyan, Sudarshna ; Zahra, Fatima ; Godbole, Madan Mohan ; Jaiswar, Shyam Pyari ; Srivastava, Vinod Kumar ; Singh Negi, Mahendra Pal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-5f7fa8ebff8a318a7fea883c463e27dfd6ba8047c6c36b41bbe7b6a22dbc8d9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>adverse effects</topic><topic>Analysis of Variance</topic><topic>Anemia</topic><topic>Anemia, Iron-Deficiency - therapy</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Antioxidant</topic><topic>antioxidant activity</topic><topic>antioxidants</topic><topic>Antioxidants - analysis</topic><topic>Biological and medical sciences</topic><topic>blood</topic><topic>cane sugar</topic><topic>Dietary Supplements</topic><topic>Diseases of red blood cells</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>ferrous sulfate</topic><topic>folic acid</topic><topic>Folic Acid - administration & dosage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>glutathione</topic><topic>Glutathione - blood</topic><topic>glutathione peroxidase</topic><topic>glutathione-disulfide reductase</topic><topic>Hematinics - administration & dosage</topic><topic>Hematologic and hematopoietic diseases</topic><topic>hemoglobin</topic><topic>Humans</topic><topic>iron</topic><topic>Iron deficiency</topic><topic>Iron supplementation</topic><topic>Iron, Dietary - administration & dosage</topic><topic>lipids</topic><topic>Medical sciences</topic><topic>Nutritional deficiency</topic><topic>Oxidant</topic><topic>Oxidative Stress</topic><topic>peroxides</topic><topic>Prospective Studies</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>vitamin A</topic><topic>women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mani Tiwari, Amit Kumar</creatorcontrib><creatorcontrib>Mahdi, Abbas Ali</creatorcontrib><creatorcontrib>Chandyan, Sudarshna</creatorcontrib><creatorcontrib>Zahra, Fatima</creatorcontrib><creatorcontrib>Godbole, Madan Mohan</creatorcontrib><creatorcontrib>Jaiswar, Shyam Pyari</creatorcontrib><creatorcontrib>Srivastava, Vinod Kumar</creatorcontrib><creatorcontrib>Singh Negi, Mahendra Pal</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mani Tiwari, Amit Kumar</au><au>Mahdi, Abbas Ali</au><au>Chandyan, Sudarshna</au><au>Zahra, Fatima</au><au>Godbole, Madan Mohan</au><au>Jaiswar, Shyam Pyari</au><au>Srivastava, Vinod Kumar</au><au>Singh Negi, Mahendra Pal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral iron supplementation leads to oxidative imbalance in anemic women: A prospective study</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>30</volume><issue>2</issue><spage>188</spage><epage>193</epage><pages>188-193</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><coden>CLNUDP</coden><abstract>Summary Background & aims This study was aimed to assess the desirable and undesirable effects of iron (100 mg/day as ferrous sulphate) and folic acid (500 μg/day) supplementation in iron deficient anemic women. Methods Iron and folic acid supplementations were given to 117 anemic women (mild = 55, moderate = 40, and severe = 22) and 60 age matched placebo treated (100 mg cane sugar) non-anemic controls for 100 days. Blood index values, oxidative stress parameters, antioxidant enzymes and vitamins were estimated as per standard protocols. Results Haemoglobin (Hb) levels along with antioxidant enzymes, namely catalase, superoxide dismutase (SOD), glutathione reductase (GSH-Rd), reduced glutathione (GSH) and total antioxidant capacity (TAC) were found significantly increased ( P < 0.01) in anemic women after treatment. However, the glutathione peroxidase (GSH-Px) and antioxidant vitamins A, C and E were found significantly decreased ( P < 0.01) in all treated groups. Lipid peroxide levels (LPO), protein carbonyl (PC), conjugated dienes (CD), lipid hydroperoxide (LOOH) and oxidized glutathione (GSSG) levels were found significantly increased ( P < 0.01) after oral iron supplementation groups. Moreover, undesirable side effects of iron supplementation were observed maximally in mild as compared with moderate and severe anemic groups, whereas nausea, vomiting, systemic reactions were negligible in all treated subjects. Conclusion Study found recommended dose of iron effective for improving Hb, but at the cost of increased oxidative stress (mild > moderate > severe). It is suggested that blind iron supplementation should be avoided and shall be provided on need basis.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20888091</pmid><doi>10.1016/j.clnu.2010.08.001</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical nutrition (Edinburgh, Scotland), 2011-04, Vol.30 (2), p.188-193 |
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| subjects | Administration, Oral Adult adverse effects Analysis of Variance Anemia Anemia, Iron-Deficiency - therapy Anemias. Hemoglobinopathies Antioxidant antioxidant activity antioxidants Antioxidants - analysis Biological and medical sciences blood cane sugar Dietary Supplements Diseases of red blood cells Feeding. Feeding behavior Female ferrous sulfate folic acid Folic Acid - administration & dosage Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology glutathione Glutathione - blood glutathione peroxidase glutathione-disulfide reductase Hematinics - administration & dosage Hematologic and hematopoietic diseases hemoglobin Humans iron Iron deficiency Iron supplementation Iron, Dietary - administration & dosage lipids Medical sciences Nutritional deficiency Oxidant Oxidative Stress peroxides Prospective Studies superoxide dismutase Superoxide Dismutase - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems vitamin A women Young Adult |
| title | Oral iron supplementation leads to oxidative imbalance in anemic women: A prospective study |
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