An fMRI study of neuronal interactions in face-selective areas of the brain

• Published in: Brain research 2010-12, Vol.1366, p.54-59
• Main Authors: Sung, Yul-Wan, Choi, Sang-Han, Hong, Soo-Jin, Choi, Uk-Soo, Cho, Jang-Hee, Ogawa, Seiji
• Format: Article
• Language: English
• Subjects: Anatomical correlates of behavior; Behavioral psychophysiology; Biological and medical sciences; Brain - blood supply; Brain - physiology; Brain Mapping; Choice Behavior - physiology; Eye and associated structures. Visual pathways and centers. Vision; Face; Face areas; Functional Laterality; Functional MRI; Fundamental and applied biological sciences. Psychology; Humans; Image Processing, Computer-Assisted - methods; Interstimulus time interval; Magnetic Resonance Imaging - methods; Neurology; Neuropsychological Tests; Oxygen - blood; Pattern Recognition, Visual - physiology; Photic Stimulation - methods; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Reaction Time - physiology; Refractory suppression; Time Factors; Vertebrates: nervous system and sense organs; Visual hemifield
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2010.10.020

Abstract Functionally activated sites usually have multiple specificities where coactivation is induced by inputs with different informational content. Using typical voxel-based functional mapping (univariate analysis), it is possible to show the presence of coactivation; however, it is not possible to distinguish whether coactivation occurs by independent or interactive processing units unless measurements are made at an extremely high spatial resolution. To address this problem, we have utilized the phenomenon of refractory suppression observable when two stimuli were given with a temporal separation of approximately 100 ms. This phenomenon is known to be noticeable in primary sensory areas. In this study, refractory suppression was investigated to determine its possible applications in higher functional sites. Two visual stimuli were presented in different hemifields, using a paradigm in which the first of the paired stimuli (face pictures) was placed in the left visual hemifield and the second stimulus was placed in the right hemifield. In this manner, the primary visual areas (V1) of the left and right hemispheres were independently activated. Along with independent activation in both V1, refractory suppression was indeed observed in higher functional areas, including the occipital and fusiform face areas in both hemispheres.