Neutrophil-Lymphocyte Ratio Predicts Medium-Term Survival Following Elective Major Vascular Surgery: A Cross-Sectional Study

Background: The systemic nature of atherosclerosis compromises medium-term survival following major vascular surgery. Neutrophil—lymphocyte ratio (NLR) is a simple index of systemic inflammatory burden which correlates with survival following percutaneous coronary intervention. Methods: Patients und...

Full description

Saved in:
Bibliographic Details
Published in:Vascular and endovascular surgery 2011-04, Vol.45 (3), p.227-231
Main Authors: Bhutta, Hina, Agha, Riaz, Wong, Joy, Tang, Tjun Y., Wilson, Yvonne G., Walsh, Stewart R.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aneurysm
Cross-Sectional Studies
Elective Surgical Procedures - mortality
Endarterectomy, Carotid - mortality
Endovascular Procedures - mortality
England
Female
Humans
Kaplan-Meier Estimate
Logistic Models
Lymphocyte Count
Lymphocytes - immunology
Male
Middle Aged
Neutrophils - immunology
Odds Ratio
Peripheral Vascular Diseases - immunology
Peripheral Vascular Diseases - mortality
Peripheral Vascular Diseases - surgery
Predictive Value of Tests
Prospective Studies
Risk Assessment
Risk Factors
Survival Rate
Time Factors
Treatment Outcome
Vascular Surgical Procedures - mortality
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: The systemic nature of atherosclerosis compromises medium-term survival following major vascular surgery. Neutrophil—lymphocyte ratio (NLR) is a simple index of systemic inflammatory burden which correlates with survival following percutaneous coronary intervention. Methods: Patients undergoing elective major vascular surgery in 2 tertiary vascular units were identified from prospectively maintained databases. Factors associated with 2-year mortality were assessed by univariate and multivariate analyses. Results: Over a 4-year period, 1021 patients underwent elective major vascular surgery (carotid endarterectomy, abdominal aortic aneurysm repair, lower limb revascularization). Two-year mortality was 11.2%. In multivariate analysis, preoperative NLR > 5 was independently associated with 2-year mortality (multivariate odds ratio [OR] 2.21; 95% confidence interval [CI] 1.22-4.01). Conclusion: Preoperative NLR identifies patients at increased risk of death within 2 years of major vascular surgery. This simple index may facilitate targeted preventive measures for high-risk patients.
ISSN:1538-5744
1938-9116
DOI:10.1177/1538574410396590