Contribution of arterial Windkessel in low-frequency cerebral hemodynamics during transient changes in blood pressure

The Windkessel properties of the vasculature are known to play a significant role in buffering arterial pulsations, but their potential importance in dampening low-frequency fluctuations in cerebral blood flow has not been clearly examined. In this study, we quantitatively assessed the contribution...

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Published in:Journal of applied physiology (1985) 2011-04, Vol.110 (4), p.917-925
Main Authors: CHAN, Gregory S. H, AINSLIE, Philip N, WILLIE, Chris K, TAYLOR, Chloe E, ATKINSON, Greg, JONES, Helen, LOVELL, Nigel H, TZENG, Yu-Chieh
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Flow Velocity - physiology
Blood pressure
Blood Pressure - physiology
Cerebrovascular Circulation - physiology
Comparative analysis
Electrocardiography
Female
Fundamental and applied biological sciences. Psychology
Hemodynamics - physiology
Humans
Intervention
Male
Middle Cerebral Artery - diagnostic imaging
Middle Cerebral Artery - physiology
Studies
Ultrasonography, Doppler, Transcranial
Veins & arteries
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container_title Journal of applied physiology (1985)
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creator CHAN, Gregory S. H
AINSLIE, Philip N
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LOVELL, Nigel H
TZENG, Yu-Chieh
description The Windkessel properties of the vasculature are known to play a significant role in buffering arterial pulsations, but their potential importance in dampening low-frequency fluctuations in cerebral blood flow has not been clearly examined. In this study, we quantitatively assessed the contribution of arterial Windkessel (peripheral compliance and resistance) in the dynamic cerebral blood flow response to relatively large and acute changes in blood pressure. Middle cerebral artery flow velocity (MCA(V); transcranial Doppler) and arterial blood pressure were recorded from 14 healthy subjects. Low-pass-filtered pressure-flow responses (
doi_str_mv 10.1152/japplphysiol.01407.2010
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H ; AINSLIE, Philip N ; WILLIE, Chris K ; TAYLOR, Chloe E ; ATKINSON, Greg ; JONES, Helen ; LOVELL, Nigel H ; TZENG, Yu-Chieh</creator><creatorcontrib>CHAN, Gregory S. H ; AINSLIE, Philip N ; WILLIE, Chris K ; TAYLOR, Chloe E ; ATKINSON, Greg ; JONES, Helen ; LOVELL, Nigel H ; TZENG, Yu-Chieh</creatorcontrib><description>The Windkessel properties of the vasculature are known to play a significant role in buffering arterial pulsations, but their potential importance in dampening low-frequency fluctuations in cerebral blood flow has not been clearly examined. In this study, we quantitatively assessed the contribution of arterial Windkessel (peripheral compliance and resistance) in the dynamic cerebral blood flow response to relatively large and acute changes in blood pressure. Middle cerebral artery flow velocity (MCA(V); transcranial Doppler) and arterial blood pressure were recorded from 14 healthy subjects. Low-pass-filtered pressure-flow responses (&lt;0.15 Hz) during transient hypertension (intravenous phenylephrine) and hypotension (intravenous sodium nitroprusside) were fitted to a two-element Windkessel model. The Windkessel model was found to provide a superior goodness of fit to the MCA(V) responses during both hypertension and hypotension (R² = 0.89 ± 0.03 and 0.85 ± 0.05, respectively), with a significant improvement in adjusted coefficients of determination (P &lt; 0.005) compared with the single-resistance model (R² = 0.62 ± 0.06 and 0.61 ± 0.08, respectively). No differences were found between the two interventions in the Windkessel capacitive and resistive gains, suggesting similar vascular properties during pressure rise and fall episodes. The results highlight that low-frequency cerebral hemodynamic responses to transient hypertension and hypotension may include a significant contribution from the mechanical properties of vasculature and, thus, cannot solely be attributed to the active control of vascular tone by cerebral autoregulation. 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source American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free
subjects Adult
Biological and medical sciences
Blood Flow Velocity - physiology
Blood pressure
Blood Pressure - physiology
Cerebrovascular Circulation - physiology
Comparative analysis
Electrocardiography
Female
Fundamental and applied biological sciences. Psychology
Hemodynamics - physiology
Humans
Intervention
Male
Middle Cerebral Artery - diagnostic imaging
Middle Cerebral Artery - physiology
Studies
Ultrasonography, Doppler, Transcranial
Veins & arteries
title Contribution of arterial Windkessel in low-frequency cerebral hemodynamics during transient changes in blood pressure
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