Bone loss during menopausal transition among southern Chinese women

Abstract Objectives Estrogen deficiency during menopausal transition is associated with rapid bone loss. The purpose of this study was to examine the time of onset, the rate, and predictors of menopausal bone loss. Study design Prospective data were analyzed from 160 Chinese women between the ages o...

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Bibliographic Details
Published in:Maturitas 2011-05, Vol.69 (1), p.50-56
Main Authors: Cheung, Elaine, Tsang, Shirley, Bow, Cora, Soong, Cissy, Yeung, Shirley, Loong, Connie, Cheung, Ching-Lung, Kan, Anita, Lo, Sue, Tam, Sidney, Tang, Grace, Kung, Annie
Format: Article
Language:English
Subjects:
Age Factors
Asian Continental Ancestry Group
Biological and medical sciences
Body Weight
Bone and Bones - pathology
Bone loss
Chinese
Diseases of the osteoarticular system
Estrogens - deficiency
Female
Follicle Stimulating Hormone - blood
Gynecology. Andrology. Obstetrics
Hong Kong
Humans
Internal Medicine
Medical sciences
Menopausal transition
Menopause - physiology
Middle Aged
Obstetrics and Gynecology
Osteoporosis, Postmenopausal - blood
Osteoporosis, Postmenopausal - prevention & control
Osteoporosis. Osteomalacia. Paget disease
Premenopause
Prospective Studies
Puberal and climacteric disorders (male and female)
Reproduction
Risk Factors
Spine
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Summary:Abstract Objectives Estrogen deficiency during menopausal transition is associated with rapid bone loss. The purpose of this study was to examine the time of onset, the rate, and predictors of menopausal bone loss. Study design Prospective data were analyzed from 160 Chinese women between the ages of 45 to 55 years who participated in the Hong Kong Osteoporotic Study. Main outcome measures All participants were studied yearly for 4 years. Demographic information, menstrual status according to the Stages of Reproductive Aging Workshop (STRAW), and lifestyle habits were recorded as well as bone mineral density (BMD) measured every visit. Baseline follicular stimulating hormone, sex hormone binding globulin, parathyroid hormones, C-terminal telopeptides of type 1 collagen, estradiol and testosterone were also measured. Results There was no significant bone loss at the spine, femoral neck and total hip in premenopausal women. Maximal bone loss occurred within the STRAW stage −2 and −1. Age at menopause, baseline age, body weight and FSH were independent predictors of bone loss. Subjects in the lowest quartile of baseline body weight (61 kg). Subjects in the highest quartile of baseline FSH (>40 IU/l) lost bone 1.3–2.3 times faster at all 3 sites compared with those in the lowest quartile (
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2011.01.010