Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Objective We have previously reported that the histologic mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. Here we sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC. Study design We evaluated the relationships bet...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2011-05, Vol.111 (5), p.587-592
Main Authors: Sato, Jun, DDS, PhD, Yamazaki, Yutaka, DDS, PhD, Satoh, Akira, DDS, PhD, Onodera-Kyan, Makiko, DDS, PhD, Abe, Takahiro, DDS, PhD, Satoh, Takehiko, DDS, PhD, Notani, Ken-ichi, DDS, PhD, Kitagawa, Yoshimasa, DDS, PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Biological and medical sciences
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Dentistry
Facial Pain
Female
Humans
Kaplan-Meier Estimate
Logistic Models
Male
Medical sciences
Middle Aged
Mouth Neoplasms - mortality
Mouth Neoplasms - pathology
Neoplasm Invasiveness
Neoplasm Staging
Otorhinolaryngology. Stomatology
Prognosis
Proportional Hazards Models
Risk Factors
Surgery
Survival Rate
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Objective We have previously reported that the histologic mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. Here we sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC. Study design We evaluated the relationships between overall survival rates and clinicopathologic variables, including gender, age, T- and N-stages, pathologic findings, and pain in 109 consecutive patients with untreated OSCC. Results Of these 109 patients, 40 (37%) reported spontaneous pain. Univariate analysis showed that the overall survival rates of patients with spontaneous pain was significantly lower than those of patients without pain ( P = .002). Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of overall survival rates. Conclusions This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2010.11.033