Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats

Vitamin K is a cofactor for γ-glutamyl carboxylase, which is an essential enzyme for the γ-carboxylation of vitamin K-dependent proteins such as osteocalcin and matrix Gla protein. Although it has been suggested that vitamin K plays an important role in the improvement of bone metabolism, the relati...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2011-05, Vol.48 (5), p.1036-1042
Main Authors: Sogabe, Natsuko, Maruyama, Rieko, Baba, Otto, Hosoi, Takayuki, Goseki-Sone, Masae
Format: Article
Language:English
Subjects:
Adipose Tissue - anatomy & histology
Adipose Tissue - drug effects
Animals
Blood Glucose - metabolism
Body Composition - drug effects
Bone Density - drug effects
Cholesterol - blood
Cytokines - blood
Diet
Dietary Supplements
Female
Femur - anatomy & histology
Femur - diagnostic imaging
Femur - drug effects
Hormones - blood
Organ Size - drug effects
Rats
Rats, Sprague-Dawley
Serum - metabolism
Time Factors
Tomography, X-Ray Computed
Triglycerides - blood
Vitamin K 1 - pharmacology
Vitamin K 2 - analogs & derivatives
Vitamin K 2 - pharmacology
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Summary:Vitamin K is a cofactor for γ-glutamyl carboxylase, which is an essential enzyme for the γ-carboxylation of vitamin K-dependent proteins such as osteocalcin and matrix Gla protein. Although it has been suggested that vitamin K plays an important role in the improvement of bone metabolism, the relationship between dietary vitamin K intake and bone metabolism has not been thoroughly investigated. Moreover, vitamin K is thought to have other actions beyond influencing the γ-carboxylation status. In the present study, we examined the effects of the long-term addition of phylloquinone (PK) or menaquinone-4 (MK-4) to a control diet on bone mineral density, bone strength, body composition, and serum parameters in rats. A total of 23 female Sprague-Dawley strain rats (6 weeks old) were divided into three groups: basic control diet group, PK diet (PK: 600mg/kg diet) group, and MK diet (MK-4: 600mg/kg diet) group. Three months after starting the experimental diet, the addition of PK to the basic control diet significantly increased the bone mineral density (BMD) of the femur (p
ISSN:1873-2763
DOI:10.1016/j.bone.2011.01.020