Impact of Acute Caffeine Ingestion on Endothelial Function in Subjects With and Without Coronary Artery Disease

• Published in: The American journal of cardiology 2011-05, Vol.107 (9), p.1255-1261
• Main Authors: Shechter, Michael, MD, MA, Shalmon, Guy, RD, Scheinowitz, Mickey, PhD, Koren-Morag, Nira, PhD, Feinberg, Micha S., MD, Harats, Dror, MD, Sela, Ben Ami, PhD, Sharabi, Yehonatan, MD, Chouraqui, Pierre, MD
• Format: Article
• Language: English
• Subjects: ACE inhibitors; Biological and medical sciences; Biomarkers; Brachial Artery - drug effects; Brachial Artery - physiology; Caffeine; Caffeine - pharmacology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Case-Control Studies; Coffee; Comparative analysis; Coronary Artery Disease; Coronary heart disease; Double-Blind Method; Effects; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Female; Heart; Humans; Male; Medical sciences; Middle Aged; Phosphodiesterase Inhibitors - pharmacology; Plasma; Regional Blood Flow
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2010.12.035

Although coffee is a widely used, pharmacologically active beverage, its impact on the cardiovascular system is controversial. To explore the effect of acute caffeine ingestion on brachial artery flow-mediated dilation (FMD) in subjects without coronary artery disease (CAD; controls) and patients with CAD, we prospectively assessed brachial artery FMD in 40 controls and 40 age- and gender-matched patients with documented stable CAD on 2 separate mornings 1 week to 2 weeks apart. After overnight fasting, discontinuation of all medications for ≥12 hours, and absence of caffeine for >48 hours, participants received capsules with caffeine 200 mg or placebo. One hour after drug ingestion, participants underwent brachial artery FMD and nitroglycerin-mediated dilation (NTG) using high-resolution ultrasound. As expected, patients with CAD were more oftein diabetic, hypertensive, obese, dyslipidemic, and smoked more than controls (p