Chemistry and Biology of Macrolide Antiparasitic Agents

Macrolide antibacterial agents inhibit parasite proliferation by targeting the apicoplast ribosome. Motivated by the long-term goal of identifying antiparasitic macrolides that lack antibacterial activity, we have systematically analyzed the structure−activity relationships among erythromycin analog...

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Bibliographic Details
Published in:Journal of medicinal chemistry 2011-04, Vol.54 (8), p.2792-2804
Main Authors: Lee, Younjoo, Choi, Jun Yong, Fu, Hong, Harvey, Colin, Ravindran, Sandeep, Roush, William R, Boothroyd, John C, Khosla, Chaitan
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antiparasitic Agents - chemistry
Antiparasitic Agents - pharmacology
Cells, Cultured
Humans
Macrolides - chemistry
Macrolides - pharmacology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Models, Molecular
Spectrometry, Mass, Electrospray Ionization
Structure-Activity Relationship
Toxoplasma - drug effects
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